Prognosis and Long Term Pubertal Outcome of Girls Previously Diagnosed With a Prenatal Ovarian Cyst

Status

Terminated

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02482467

Acronym

KYSTOV

Enrollment

105

Registered

2015-06-26

Start date

2014-11-24

Completion date

2025-05-07

Last updated

2025-05-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ovarian Cyst

Keywords

ovarian cyst, prenatal diagnosis, puberty

Brief summary

Puberty and long-term ovarian function of patients with a ovarian prenatal cyst has not described to date.

Detailed description

The prenatal diagnosis of ovarian cysts is a common disease with an estimated incidence of 1 case per 2500 births. This pathology is the first diagnosis of abdominal cystic picture on the female fetus in the third trimester of pregnancy.Various complications of ovarian cysts have been described, such as ovarian torsion, breaking the cyst, hemorrhage intra cystic and compression of adjacent viscera. A conservative attitude for uncomplicated cysts is proposed in the literature but surgical care and / or puncture can be made to prevent the occurrence of complications and thus to protect ovarian tissue.However, no data on puberty and long-term ovarian prognosis in this disease is published in the literature. Without this information, no support for the recommendation of a prenatal ovarian cyst can be established formally.

Interventions

OTHERHormonal analysis, pelvic US

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

6 Years to 24 Years

Healthy volunteers

Yes

Inclusion criteria

* Collection of the written consent by the patients or the parents * Membership in a health insurance scheme * Group 1 : girl with prenatal ovarian cyst group 2: girl without prenatal ovarian cyst

Exclusion criteria

* Refusal of participation of the patient or one of the two parents * Deprived of freedom * Pregnancy and current feeding * Prenatal, neonatal or infantile history of ovarian pathology (Group 2) * Genital congenital deformation or malformation syndrome gives a complex (group 2) * Endocrine pathology except the juvenile disorders (group 2)

Design outcomes

Primary

Measure	Time frame	Description
Age of puberty	1 day	Clinical data and clinical history

Secondary

Measure	Time frame	Description
Follicular reserve	1 day	Serum level of Anti-Mullerian Hormone and ovarian volume at ultrasonography

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026