STI Combined to Valsalva Maneuver for the Diagnosis of Left Ventricular Dysfunction in COPD Exacerbations

a New and Non Invasive Method to Calculate STI ( Systolic Time Intervals) Combined to Valsalva Maneuver in Patient With Acute Exacerbation of COPD

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02481908

Acronym

STICOPD

Enrollment

189

Registered

2015-06-25

Start date

2012-04-30

Completion date

2013-12-31

Last updated

2020-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obstructive Chronic Bronchitis With Acute Exacerbation

Keywords

AECOPD, left ventricular dysfunction, valsalva maneuver, systolic time intervals

Brief summary

The aim of this investigation was to assess the value of Systolic Time Intervals (STIs) as a method of detecting Left Ventricular Dysfunction (LVD) in patients admitted to the emergency department for cute exacerbations of chronic obstructive pulmonary disease (AECOPD) and whether STIs measured under Valsalva manoeuver (VM) could improve the distinction between patients with LVD and those without LVD.

Detailed description

We included patients admitted to the ED for AECOPD. Measurement of STIs included electromechanical activation time (EMAT), left ventricular ejection time and EMAT/LVET ratio. These were performed at baseline and during the first strain phase of the VM using a computerized phono and electrocardiographic method. The diagnosis of LVD was determined on the basis of clinical examination, echocardiography and brain natriuretic peptide. The values of STIs were compared between patients with and without LVD ; their diagnostic performance was assessed using the area under receiver operating characteristic curve (AUC of ROC).

Interventions

DEVICESTI measurements at baseline and under Valsalva maneuver

STI measurements at baseline and under Valsalva maneuver

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Oxygen Saturation (SPO2) \<90%, * Respiratory Rate \>25c/min, * PaCO2 \> 6 kPa et pH\< 7.35.

Exclusion criteria

* Neurological distress and hemodynamic instability * Confusion, agitation * pneumothorax * Non cooperative patients * Refusal of consent

Design outcomes

Primary

Measure	Time frame	Description
diagnosis of left ventricular dysfunction	during the first day admission in emergency department	Systolic time intervals measured at baseline and under Valsalva maneuver

Countries

Tunisia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026