Fasciculation
Conditions
Keywords
Cisatracurium, Myalgia, Fasciculation, Succinylcholine
Brief summary
The purpose of this study is to investigate the effects of different doses of cisatracurium pretreatment on succinylcholine-induced fasciculations and postoperative myalgia.
Detailed description
Purpose: To investigate the effects of different doses of cisatracurium pretreatment on succinylcholine-induced fasciculations and postoperative myalgia. Methods: Ninety patients scheduled for laparoscopic cholecystectomies were equally randomized into three groups to receive pretreatment of 0.005, 0.01, and 0.02 mg/kg cisatracurium, respectively. General anesthesia was induced 3.5 min later, train of four stimulation was monitored 4.5 min later, succinylcholine 1.5 mg/kg was injected 5 min later, and endotracheal intubation was implemented 6.5 min later. The side effects of cisatracurium, intensity of fasciculations, intubating conditions, time and extent to maximal depression of twitch and time for its recovery to 20% of control value, severity of myalgia at 24 h postoperatively, serum potassium before the induction, at the time of endotracheal intubation, and 5 min after intubation were recorded.
Interventions
DRUGCisatracurium
Different doses of cisatracurium pretreatment
Sponsors
Yangzhou No.1 People's Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* American Standards Association (ASA) physical status I or II patients scheduled for elective laparoscopic cholecystectomies with tracheal intubation requiring general anesthesia * 20 - 65 years old * without acid-base imbalance and electrolyte disturbance * with normal hepatic and renal function
Exclusion criteria
* Patients with known hyperkalemia * Patients with increased intraocular pressure * Patients with increased intracranial pressure * Patients with symptoms of gastroesophageal reflux * Patients with anticipated airway difficulties * Patients with malignant fever * Patients with neuromuscular disease * Patients with burn or crush injuries * Patients with taking drugs known to alter the action of neuromuscular blockers * Patients with with a body mass index exceeding 30
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The presence of fasciculations | After the injection of succinylcholine for 1.5 minutes |
Secondary
| Measure | Time frame |
|---|---|
| The time to maximal depression of twitch | From the time of 4.5 minutes after the pretreatment of cisatracurium for two minutes |
| The extent to maximal depression of twitch | From the time of 4.5 minutes after the pretreatment of cisatracurium for two minutes |
| The time for twitch recovery to 20% of its control value | From the time of 4.5 minutes after the pretreatment of cisatracurium for two minutes |
| Side effects of the pretreatment of cisatracurium | At the time of three minutes after the pretreatment of cisatracurium |
| The changes of serum potassium | After entering the operating theater till the anesthesia induction, at intubating, and 5 min after intubation |
| Myalgia at 24 hours postoperatively | At 24 hours postoperatively |
| The grades of endotracheal intubation | At intubating time |
Outcome results
None listed