Female Breast Cancer, Male Breast Cancer
Conditions
Brief summary
The aim of this study is to define silent breast cancer prevalence in both sexes and will be held by biopsies performed in imaging suspicious areas of the breast (ecography and mammography) in cadavers without known breast cancer.
Detailed description
Cadavers of both sexes are going to be submitted to bilateral mastectomy. The specimens are going to be examined by palpation, ecography and mammography and all areas with (Breast Imaging Reporting and Data System) BI-RADS classification \>= 3 are going to be biopsied. Biopsy specimens are going to be processed by the pathology department and cancers are going to be identified and classified by their molecular type. The investigators intend to know which is the disease reservoir in various ages.
Interventions
OTHERBiopsy
Biopsy of BI-RADS 3 and superior lesions
PROCEDUREBilateral mastectomy
Bilateral mastectomy and imaging study of cadaveric breasts
Sponsors
Instituto Nacional de Medicina Legal e Ciências Forenses, Delegação do Sul
Centro Hospitalar Lisboa Ocidental
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Female and male cadavers above 40 years
Exclusion criteria
* Known breast cancer * Breast tissue accidental damage
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Silent breast cancer prevalence | 2 years | To define the existing disease that did not caused death in both sexes |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Silent breast cancer prevalent molecular profile | 2 years | To identify those molecular subgroups of the disease that remain silent |
Outcome results
None listed