Dyslipidemia
Conditions
Brief summary
The effects of consuming a sodium-bicarbonated mineral water rich in bicarbonate, sodium, chloride, lithium and silicon are studied in humans. The aim of this assay was to determine whether the consumption of this water as part of the usual diet, reduces cardiometabolic risk factors in adult men and women.
Interventions
DIETARY_SUPPLEMENTMineral water
Intake of 1 L per day of the mineral water (BW or CW) with main meals, crossover design
Sponsors
National Research Council, Spain
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy adults, men and women \>18 and ≤ 45 years * Total-cholesterol \> 200 mg/dL and \< 300 mg/dL
Exclusion criteria
* Age \<18 and \> 45 years * Total-cholesterol ≥300 mg/dL * Triglycerides \> 250 mg/dL * Total-cholesterol / HDL-cholesterol \> 6 * Being a usual consumer of carbonic mineral water * BMI \< 20 and \>30 kg/m2 * Diabetes * Hypertension or digestive, liver or renal disease * Eating disorders * Being under medication that could affect lipid metabolism * Consumption of functional foods that could affect lipid metabolism (food containing n-3 fatty acids or phytosterols)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| LDL-cholesterol | Baseline |
Secondary
| Measure | Time frame |
|---|---|
| Oxidized LDL | Baseline |
| Serum aldosterone | Baseline |
| BMI | Baseline |
| Dietary energy intake | Baseline |
| Dietary protein intake | Baseline |
| Dietary fat intake | Baseline |
| Dietary cholesterol intake | Baseline |
| Dietary carbohydrate intake | Baseline |
| Urine potassium | Baseline |
| Urine sodium | Baseline |
| Diastolic Blood Pressure | Baseline |
| Systolic Blood Pressure | Baseline |
| Total-cholesterol | Baseline |
| Triglycerides | Baseline |
| HDL-cholesterol | Baseline |
| Apolipoprotein A | Baseline |
| Apolipoprotein B | Baseline |
| Glucose | Baseline |
| Insulin | Baseline |
| Urine creatinin | Baseline |
| Urine calcium | Baseline |
| Urine pH | Baseline |
Outcome results
None listed