Serum Autotaxin Levels in Cholestasis of Pregnancy

Diagnostic Accuracy of Serum Autotaxin Levels in Cholestasis of Pregnancy

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02480478

Enrollment

Registered

2015-06-24

Start date

2015-06-30

Completion date

2017-01-31

Last updated

2016-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intrahepatic Cholestasis of Pregnancy

Keywords

Intrahepatic Cholestasis of Pregnancy

Brief summary

Intrahepatic cholestasis of pregnancy is the most common liver disease in pregnancy. It is is a pregnancy-specific liver disorder with onset mainly in the third trimester of pregnancy. ICP is characterized by pruritus, elevated serum fasting bile salts and transaminases and an increased risk of adverse fetal outcomes. Serum autotaxin levels were found highly sensitive and specific biomarker to to differentiate ICP from other pregnancy-related liver disorders or pruritic dermatoses. The purpose of the study is to determine the diagnostic accuracy of serum autotaxin activity in cholestasis of pregnancy.

Detailed description

Collected data will enable us to compare serum autotaxin levels in cholestasis of pregnancy and healthy control group.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Clinical diagnosed cholestasis of pregnancy patients

Exclusion criteria

* acute or chronic liver disease * acute or chronic gallbladder disease

Design outcomes

Primary

Measure	Time frame
Serum autotaxin levels in cholestasis of pregnancy	one year

Countries

Turkey (Türkiye)

Contacts

Primary ContactHakan Erenel, MD,OBGYN

hakanerenel@yahoo.com00905063092995

Outcome results