Obesity
Conditions
Keywords
metabolic alterations
Brief summary
Background: Obesity is associated with multiple diseases. Bariatric surgery is the most effective therapy for severe obesity that cannot only reduce body weight but also obesity-associated morbidity. Objective: The metabolic alterations associated with obesity and respective changes after bariatric surgery are incompletely understood. Design: In the longitudinal observational study, the investigator applied a 1H-NMR-based global, untargeted metabolomics strategy on human serum samples that were collected before and repeatedly up to one year after distinct bariatric procedures (sleeve gastrectomy, proximal and distal Roux-en Y gastric bypass; RYGB). For comparison, the investigator also analyzed serum samples from normal-weight and less obesity obese subjects that were matched for 1-year postoperative BMI values of the surgical groups.
Interventions
PROCEDUREbariatric surgery (sleeve resection, proximal RYGB, distal RYGB)
Sponsors
University of Florence
FiorGen Foundation, Italy
eSwiss Medical & Surgical Center
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI \>/=35 kg/m2 * at least 2 years of unsuccessful conservative weight loss attempts
Exclusion criteria
* \< 18 years of age * BMI \< 35 kg/m2 * informed consent was not signed by the patient
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| compare the NMR metabolic fingerprint as assessed in serum samples of severely obese patients with that of normal-weight control subjects | pre operative |
| follow up changes in the metabolic fingerprint over one year after 3 distinct bariatric procedures | pre operative, 3-, 6-, 9- and 12 months post operative |
| compare the metabolic fingerprints established one year after the different surgeries with those of BMI-matched and normal-weight control subjects | 12 months post operative |
Outcome results
None listed