Arthritis, Juvenile
Conditions
Brief summary
This research is being done to see if resistance exercise (RE) is safe and has a positive effect on children and young adults with juvenile idiopathic arthritis (JIA). JIA is an inflammatory autoimmune disease that can cause severe impairment and disability. JIA can cause bone loss and decreased muscle strength. The medications used to treat JIA can also have negative effects on growth and development, strength, and ability to function. RE is performing movements in a slow and controlled fashion (i.e., no speeding up or using force in the lifting and lowering of the weight) to lessen force on the joints and tissues. This study will be using Ren-Ex exercise equipment to perform RE. Currently the American College of Rheumatology recommends exercise for patients with arthritis. This exercise includes range of motion exercise to protect joint mobility as well as low resistance and aerobic exercise (AE) to protect muscle mass, bone health, and fitness. However, a recent study showed no major differences in functionality or quality of life between patients who performed AE and those who did not perform AE. There is a need for more data on the impact of RE on children with JIA. Children and young adults aged 10 to 21 with juvenile idiopathic arthritis may join.
Interventions
OTHERRen-Ex Machine
The exercise is performed once per week with individualized instruction using moderate resistance on Ren-Ex Machines, ultra-low-friction equipment to minimize force on joints.
OTHERDual-Emission X-ray Absorptiometry (DEXA) scan
To study body composition
OTHERBiodex dynamometer
To study muscle strength
OTHERSub-maximal test
To study lung capacity, a sub-maximal (limited exercise) test on a stationary bicycle is performed.
OTHERQuality of life questionnaires
Sponsors
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Johns Hopkins University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Intervention model description
Control and participant groups.
Eligibility
Sex/Gender
ALL
Age
10 Years to 21 Years
Healthy volunteers
No
Inclusion criteria
* American College of Rheumatology criteria for polyarticular JIA * Stable medical therapy
Exclusion criteria
* Non-English speaking * Pregnancy * Currently breast feeding * Cognitive impairment as determined by PI (patient is not responsible for making their own health care decisions)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Total Body Dual-Emission X-ray Absorptiometry (DEXA) Scan | Baseline and 12 weeks | Total and lean body mass and fat mass will be determined |
| Change in BMI | Baseline and 12 weeks | — |
| Change in Lower and upper extremity strength testing | Baseline and 12 weeks | Isokinetic strength testing with a Biodex dynamometer to measure peak torque |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in C-reactive protein (CRP) | Baseline and 12 weeks | — |
| Number of Participants with Adverse Events as a Measure of Safety and Tolerability | Baseline and 12 weeks | — |
| Change in Erythrocyte sedimentation rate (ESR) | Baseline and 12 weeks | — |
| Change in Quality of Life | Baseline and 12 weeks | Questionnaire administration |
Countries
United States
Outcome results
None listed