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Protein Requirements in Endurance-trained Athlete

Evaluation of Protein Requirements in Male Endurance Athletes

Status
Completed
Phases
Early Phase 1
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02478801
Acronym
EP
Enrollment
9
Registered
2015-06-23
Start date
2015-03-31
Completion date
2016-05-31
Last updated
2016-06-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy, Increased Metabolic Requirement

Brief summary

Protein requirements in individuals who participate in endurance-based exercise training have been suggested to be greater than the current recommended dietary allowance (RDA). Nutritional requirements for dietary amino acids in adults have traditionally been determined utilizing the nitrogen balance technique, which is prone to underestimating protein requirements. As a result, there is a need to re-evaluate recommendations in order to characterize how dietary amino acid needs may be modulated by physical activity. Recent studies using the minimally invasive indicator amino acid oxidation (IAAO) technique have suggested that protein requirements in young men are at least 50% higher than RDA based on nitrogen balance data. Therefore, the purpose of this study is to measure the protein requirement in endurance trained adults using the IAAO technique.

Interventions

DIETARY_SUPPLEMENTamino acids intake

amino acids intakes will be varied at 0.2-2.8 g/kg/day

Sponsors

Ajinomoto Co., Inc.
CollaboratorINDUSTRY
University of Toronto
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE

Eligibility

Sex/Gender
MALE
Age
18 Years to 35 Years
Healthy volunteers
Yes

Inclusion criteria

* Healthy, male, endurance-trained participants who regularly more than 40 km/week * Ability to perform the exercise stimulus (20 km run) on metabolic trial.

Exclusion criteria

* Inability to meet health and physical activity guidelines according to the physical activity readiness questionnaire (PAR-Q+) * Inability to adhere to any of the protocol guidelines (i.e. alcohol, caffeine consumption) * Regular tobacco use * Illicit drug use

Design outcomes

Primary

MeasureTime frame
13CO2 (carbon dioxide) excretion (μmol/kg/h)4 hours / study day

Secondary

MeasureTime frame
[13C]phenylalanine oxidation (μmol/kg/h)4 hours/study day

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 1, 2026