Dysgeusia, Liver Cirrhosis
Conditions
Brief summary
The purpose of this study is to evaluate the effect of zinc supplementation in the treatment for dysgeusia, progression disease and quality of life in patients with liver cirrhosis.
Detailed description
Taste disorders are symptomatologies in patients with cirrhosis, these have a direct effect in modification of food consumption, increasing weight loss, anorexia and malnutrition, which impacts in decompensation rates and mortality. It has been proposed that zinc deficiency is one of the causes for development of taste disorders. The aim of this study is to describe the presence of taste disorders in patients with cirrhosis and evaluate the effect of zinc supplementation in treatment of taste disorders, and in progression of chronic liver disease.
Interventions
DIETARY_SUPPLEMENTzinc gluconate
Zinc supplementation plus nutritional education
DIETARY_SUPPLEMENTPlacebo
BEHAVIORALNutritional education
Sponsors
Fundación Clínica Médica Sur
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Cirrhotic patients by any etiology, with any dysgeusia
Exclusion criteria
* Patients with hepatic encephalopathy at the time of dysgeusia evaluation * Patients with any neurological disease * Patients with respiratory diseases ath the time of dysgeusia evaluation * Patients with active alcohol consumption
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Dysgeusia | Presence of any taste disorder at 6 months | Evaluation of presence of any taste disorder, according to questionnaires and evaluation of perception and recognition thresholds with ascending molar concentrations of basic tastes. |
Countries
Mexico
Contacts
Primary ContactNorberto C Chávez-Tapia, PhD
Backup ContactEva Juárez-Hernández
Outcome results
None listed