Acute Lung Injury, Coagulation; Intravascular, Inflammation, Metabolic Disturbances, Postoperative; Dysfunction Following Cardiac Surgery
Conditions
Brief summary
The purpose of the present study is to visualize the inflammatory response and coagulation disorders during cardiac surgery in order to identify possible predictors for acute lung injury postoperatively.
Detailed description
Acute lung injury after cardiac surgery is a common complication. The pathophysiology is complex and still not fully elucidate. No specific biomarkers are identified and the diagnosis is solely based on impaired oxygenation. The purpose of the present study is to identify biomarkers of inflammation and coagulation in blood withdrawn simultaneous from the pulmonary artery and the left atrium during surgery and up to 20 hours after weaning from cardiopulmonary bypass.
Interventions
OTHERNo intervention
No treatment
Sponsors
Aalborg University
Aalborg University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Elective surgery * CABG * In treatment with statins
Exclusion criteria
* Acute surgery * Valve replacement * In treatment with immunodepressive drugs
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Acute lung injury measured as the fraction of partial pressure of oxygen divided by the fraction of inspired oxygen | Evaluated 72 hours after weaning from cardiopulmonary bypass (CPB) | Arterial blood gas analysis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Interleukin-2 | The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB; and exactly 48 and 72 hours after weaning from CPB | Measured in blood samples from radial artery, pulmonary artery and left atrium |
| Interleukin-4 | The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB; and exactly 48 and 72 hours after weaning from CPB | Measured in blood samples from radial artery, pulmonary artery and left atrium |
| Interleukin-6 | The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB; and exactly 48 and 72 hours after weaning from CPB | Measured in blood samples from radial artery, pulmonary artery and left atrium |
| Interleukin-8 | The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB; and exactly 48 and 72 hours after weaning from CPB | Measured in blood samples from radial artery, pulmonary artery and left atrium |
| Interleukin-10 | The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB; and exactly 48 and 72 hours after weaning from CPB | Measured in blood samples from radial artery, pulmonary artery and left atrium |
| Tumor necroting factor-alpha | The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB; and exactly 48 and 72 hours after weaning from CPB | Measured in blood samples from radial artery, pulmonary artery and left atrium |
| Interleukin-1beta | The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB; and exactly 48 and 72 hours after weaning from CPB | Measured in blood samples from radial artery, pulmonary artery and left atrium |
| Granulocyte-macrophage colony-stimulating factor | The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB; and exactly 48 and 72 hours after weaning from CPB | Measured in blood samples from radial artery, pulmonary artery and left atrium |
| Thrombin-antithrombin complexes | The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB | Measured in blood samples from pulmonary artery and left atrium |
| Plasmin-antiplasmin complexes | The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB | Measured in blood samples from pulmonary artery and left atrium |
| D-dimer | The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB | Measured in blood samples from pulmonary artery and left atrium |
| Thrombin Fragment 1.2 | The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB | Measured in blood samples from pulmonary artery and left atrium |
| Metabolomics | The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB; and exactly 48 and 72 hours after weaning from CPB | Metabolomics using the NMR-technique in blood samples from radial artery, pulmonary artery and left atrium |
| Interferon-gamma | The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB; and exactly 48 and 72 hours after weaning from CPB | Measured in blood samples from radial artery, pulmonary artery and left atrium |
Outcome results
None listed