Muscles Ischemia
Conditions
Brief summary
Clinical, Biochemical and Neurophysiological Consequences of Intraoperative Tourniquet During Total Knee Arthroplasty: WOMAC-Score Knee-Score Radiographic Evaluations and Scoring System Biochemical muscle biopsy analysis
Detailed description
Biochemistry: Analysis of the muscles biopsies Clinical: Bloodloss, Complications, WOMAC-Score, Knee-Score Radiographics: Evaluations and Scoring System Neurophysiology Evaluation of N. femoralis
Interventions
PROCEDURETotal knee arthroplasty
Total knee arthroplasty
Sponsors
Universitätsmedizin Mannheim
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
55 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* Age = 55-85 years * Osteoarthritis of knee joint (degree III or IV) * Physical status (ASA I or II) * Body mass index \< 45 kg/m² * Written informed consent
Exclusion criteria
* Age \<55 or \> 85years * Osteoarthritis knee joint (degree I or II) * Physical status (ASA III or IV) * Body mass index ≥ 45 kg/m² * Unable to provide written consent * Malignant disease * Rheumatoid disease * Infectious disease * Coagulation disorder * History of deep vein thrombosis or pulmonary embolism * Peripheral arterial disease * Immune deficiency * Medication (Glucocorticoid, Aspirin, Heparin, Cumardine, Wafarin) * Neurological dysfunction * Liver insufficiency * Coronary heart disease * Immobility
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Biochemical Data | During operation 60 min Ischemia/Shame-Ischemia Time | Measurement of intracellular proteolytic activity |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Electrophysiological Evaluation of the N. femoralis | 1 Week postoperative | Nerve function analysis |
| Bloodloss | 1 week postoperative | — |
| Complications | 6 months postoperative | — |
| Clinical Scores | 6 months postoperative | WOMAC-Score, Knee-Score |
| Radiographic Scores | 1 Week postoperative | Prosthesis Position on radiographs |
Countries
Germany
Contacts
Primary ContactAhmed Jawhar, Dr
Outcome results
None listed