End-stage Renal Disease
Conditions
Keywords
nephrology, extra-renal purification, peritoneal dialysis
Brief summary
The aim of this study is to demonstrate the efficiency of an adapted and alternate peritoneal dialysis scheme in terms of sodium extraction and purification compared to an adapted conventional peritoneal dialysis scheme.
Interventions
OTHERcomparison of two regimens in peritoneal dialysis
Dialysate samples (8 by scheme, volume of 10 mL) are collected at each cycle (one at the beginning and one at the end of the cycle). A blood sample (5 mL) is collected at the beginning of the second scheme and a 24-hour urine sample at the end of the second scheme.
Sponsors
Centre Hospitalier Universitaire de Besancon
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients hospitalized in the Nephrology department of the Besançon University Hospital * Patients treated by continuous ambulatory peritoneal dialysis or ambulatory peritoneal dialysis for at least 6 months * Absence of hospitalization caused by an infection in the month prior to inclusion * Patients with a ratio (D / P) of the concentration of creatinine in the blood and dialysate between 0.5 and 0.8 on a checkup of less than 1 year. * No contraindication to the use of hypertonic bag * Signature of informed consent for participation indicating that the subject has understood the purpose and procedures required by the study and agrees to participate in the study and comply with the requirements and limitations inherent in this study * Affiliation to a French social security system or beneficiary
Exclusion criteria
* Legal incapacity or limited legal capacity * Patients unlikely to cooperate in the study and/or low cooperation anticipated by the investigator * Patients without health insurance * Pregnant women * Patient being in the exclusion period from another study or planned by the national register of volunteers * Hospitalization caused by an infection in the month prior to inclusion * Patients with a peritoneal dialysis catheter dysfunction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intra-dialytic concentrations of different electrolytes (sodium, phosphorus, urea, creatinine, glucose and proteins) | In a maximum of 72 hours after collection |
Countries
France
Outcome results
None listed