Improving Motor Stroke Recovery Using Patient-tailored Non-invasive Brain Stimulation

Towards More Successful Clinical Trials: Using a Patient-tailored Approach in Brain Stimulation to Improve Recovery of Movements After Stroke

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02473549

Enrollment

Registered

2015-06-16

Start date

2017-09-01

Completion date

2021-06-30

Last updated

2022-06-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Keywords

motor, rehabilitation, transcranial direct current stimulation

Brief summary

Many individuals are often left with problems moving their arm and hand, months to even years after a stroke. Recent progress in research suggests the application of non-invasive brain stimulation, such as transcranial direct current stimulation (TDCS), in conjunction with rehabilitation exercises can further improve a person's ability to move after stroke. However, the problem is that this doesn't work for everyone, and researchers do not know why. One reason may be that TDCS is currently applied using a one-size-fits-all approach. Researchers apply the same type of TDCS to everyone, assuming the stroke affects everyone in the same way. But, researchers know this is not the case. For example, each person will likely have different amounts of damage to brain regions that control movements. A better understanding of how the stroke uniquely affects a person's brain will help us to know which is the correct type of TDCS to apply for that person. Therefore, the objective of this research is to determine whether the amount of damage to brain regions that control movements can predict which type of TDCS will be more effective to help a person improve their ability to move. Participants will undergo 1 session of magnetic resonance imaging, and three sessions of TDCS.

Interventions

DEVICESham TDCS

Placebo stimulation is applied to the unaffected motor cortex while participants perform rehabilitation exercises for the upper extremity

DEVICEAnodal TDCS

Excitatory stimulation is applied to the unaffected motor cortex while participants perform rehabilitation exercises for the upper extremity

DEVICECathodal TDCS

Inhibitory stimulation is applied to the unaffected motor cortex while participants perform rehabilitation exercises for the upper extremity

DEVICEMagnetic Resonance Imaging (MRI)

Participants will receive a MRI of their brain to allow the research investigators to determine how the stroke has affected regions of the brain processing movements.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* unilateral first time stroke in middle cerebral artery territory * greater 3 months post-stroke * able to raise arm onto a table from a seated position

Exclusion criteria

* severe cognitive or comprehension deficits that may compromise informed consent or understanding of instructions * severe apraxia and neglect * neurodegenerative or psychiatric disease * contraindications to MRI and TDCS (e.g. metal in head, pacemaker, claustrophobia)

Design outcomes

Primary

Measure	Time frame
Change in movement time (seconds) for reaching after 1 session of TDCS	1 day
Change in accuracy of reaching (root mean square error) after 1 session of TDCS	1 day
Change in efficiency of reaching (number of velocity peaks) after 1 session of TDCS	1 day

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026