Horton Disease
Conditions
Brief summary
The study aims at measuring the sensitivity and specificity of a series of imaging signs (recorded by magnetic resonance angiography, vascular tomodensitometry, vascular ultrasonography, retina angiography and retina optic coherence tomography) for the diagnosis of Horton disease, the gold standard being the result of temporal artery biopsy.
Interventions
RADIATIONVascular tomodensitometry
OTHERMagnetic resonance angiography
OTHERRetinal angiography
OTHERRetinal optical coherence tomography
Sponsors
Fondation Ophtalmologique Adolphe de Rothschild
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients admitted to the Fondation Ophtalmologique Adolphe de Rothschild and suspected to suffer from Horton disease, based on the presence of 3 or more major criteria, or 2 major criteria and at least one minor criteria. Major criteria : Age \> 50 ans ; headache ; intermittent jaw or tongue pain ; visual impairment ; ESR \> 50 mm at 1h and/or CRP \> 8mg/l. Minor criteria: temporal artery or scalp tenderness ; facial pain or tenderness ; fever \>38°C, weight loss \>10%, anorexia, fatigue.
Exclusion criteria
* Autoimmune disease * Active infectious condition * Malignant disease * Condition counterindicating one or several of the protocol's imaging procedures : allergy to iodine and/or renal insufficiency and/or claustrophobia and/or metallic foreign body...
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| MRI angiography mural inflammation | Baseline | Presence of signs of artery mural inflammation in T1 sequence of MRI angiography |
Countries
France
Outcome results
None listed