Myasthenia Gravis
Conditions
Keywords
Myasthenia gravis, Quality of life
Brief summary
The purpose of this study is to translate and culturally adapt the MGQOL-15 (health-related quality of life scale for myasthenia gravis) for use with French-speaking patients in France and to evaluate its psychometric properties to ensure reliability and validity.
Detailed description
It is a translation and validation of a quality of life scale. Step 1: Translation and cultural adaptation (Forward and back translation, committee review, pre-testing with 10 patients for content and face validity). Step 2 : Psychometric testing : Test-retest with a 2 day interval, correlation with clinical scores - the Myasthenic Muscle Score and the (MG-ADL) score and with a global quality of life score (WHOQOL-BREF).
Interventions
None listed
Sponsors
Assistance Publique - Hôpitaux de Paris
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Auto-immune myasthenia gravis * Age ≥ 18 years old * Clinical Classification (MGFA) I-IV * French speaking
Exclusion criteria
* cognitive or visual impairment which would limit the capacity to fill out the MGQOL-15-F
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Perceived quality of life measured via the MGQOL-15-F (French version of the MGQOL-15), a myasthenia-specific quality of life auto-questionnaire | 3 days |
Secondary
| Measure | Time frame |
|---|---|
| Global quality of life evaluated via the WHOQOL-BREF scale | 1 day |
| Clinical evaluation : Myasthenic Muscle Score | 1 day |
| Disease severity assessed via the Myasthenic Muscle Score | 1 day |
| Impact of symptoms on daily activities and daily life using the MG-ADL score | 1day |
Countries
France
Outcome results
None listed