Respiratory Mechanics and Metabolic Changes During Low Pressure Laparoscopic Cholecystectomy

The Impact of Deep Versus Moderate Neuromuscular Block on Respiratory System Mechanics and Metabolic Changes During Laparoscopic Cholecystectomy a Double-Blind Randomized Clinical Trial.

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02469831

Enrollment

Registered

2015-06-12

Start date

2014-10-31

Completion date

2016-01-31

Last updated

2017-03-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Laparoscopic Cholecystectomy

Brief summary

The investigators aim to investigate the differences between deep continuous muscle relaxation and moderate blockade during low-pressure (8 mmHg) laparoscopic cholecystectomy in respect to metabolic changes and respiratory mechanics.

Interventions

DRUGRocuronium

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Inclusion criteria

* more than 18 years * undergoing elective laparoscopic cholecystectomy

Exclusion criteria

* previous surgeries, * a history of venous or arterial diseases, * BMI (≥30 kg/m2), * Allergy to rocuronium. * Significant liver dysfunction. * Significant renal dysfunction (S-creatinine \> 200 umol/l). * Neuromuscular disease that might impair neuromuscular blockade * Pregnant or breastfeeding. * Indication for rapid sequence induction. * Inability to informed consent

Design outcomes

Primary

Measure	Time frame	Description
respiratory mechanics (Dynamic compliance)	intraoperative	Dynamic compliance

Secondary

Measure	Time frame	Description
surgeon satisfaction (scale from 1 to 5)	intraoperative	scale from 1 to 5
postoperative pain (VAS score)	postoperative for 6 hours	VAS score
postoperative nausea and vomiting	postoperative for 6 hours	—
completion of surgical procedure	intraoperative	yes or no
metabolic changes (blood lactate)	intraoperative	blood lactate

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026