Does Coffee Intake Reduce Postoperative Ileus After Elective Colorectal Surgery

Does Coffee Intake Reduce Postoperative Ileus After Elective Colorectal Surgery - a Prospective, Randomized Controlled Study - the COFFEE STUDY

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02469441

Acronym

COFFEE

Enrollment

136

Registered

2015-06-11

Start date

2014-08-01

Completion date

2016-12-31

Last updated

2017-01-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Ileus

Keywords

coffee, postoperative ileus, colorectal surgery

Brief summary

The aim of the study is to investigate if postoperative coffee intake decreases the time until first bowel movement in elective colorectal surgery with primary anastomosis.

Detailed description

Postoperative ileus after colorectal surgery is a frequent problem which significantly prolongs hospital stay and increases perioperative costs. Postoperative therapeutic interventions vary significantly between different hospitals due to missing evidence-based guidelines. Coffee is a safe, cheap and simple agent without significant side effects which can positively influence the bowel function. The aim of the investigators is to evaluate in an own study if coffee consumption has an influence on the duration of postoperative ileus. The present trial is designed to evaluate if postoperative coffee intake decreases the time until first bowel movement in colorectal surgery with primary anastomosis. This study would be the second study which evaluates the described questions under randomized conditions.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Patients scheduled for elective laparoscopic or open colorectal surgery due to benign or malignant colorectal disease, which need a large bowel resection with primary anastomosis * Age equal or greater than 18 years * Patients that are able to give informed consent * Elective Surgery * Anastomosis above 6 cm from anal verge

Exclusion criteria

* Participation in other studies * Additional small bowel anastomosis * Need for extended adhesiolysis * Need for a stoma (e.g. protective ileostomy) * Emergency operation with diffuse peritonitis or preexisting ileus * Preoperative radiation * Known hypersensitivity or allergy to coffee * Expected lack of compliance * Impaired mental state or language problems

Design outcomes

Primary

Measure	Time frame	Description
Time to first bowel movement	Follow-up per patient: 1 month postoperatively	Time to first bowel movement (time from the end of surgery until the first passage of stool recorded by nursing staff) as a marker for the termination of postoperative ileus.

Countries

Switzerland

Outcome results