Acute Lung Injury
Conditions
Keywords
Xenon, Standford A acute aortic dissection
Brief summary
Acute lung injury (ALI) is the vital complication of Stanford type A aortic dissection. It is confirmed that Xenon has the significant protective effect on important organs and has no suppression on the cardiovascular system. Furthermore, our earlier trial has already clarified that static inflation with 50% Xenon during cardiopulmonary bypass could attenuate ALI for Standford A acute aortic dissection. However the protection effect was restricted for the limited time. Aimed to enhance the protection effect of Xenon, we designed this randomized trial that anesthesia with 50% xenon one hour before and after CPB and pulmonary static Inflation with 50%,75% and 100% Xenon during CPB respectively.
Interventions
OTHERoxygen
50% oxygen inhalation
DRUGXenon
50% Xenon inhalation
Sponsors
Beijing Anzhen Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
Consultant's clinical diagnosis of Stanford type A AAD using local pathways of diagnosis, which may include clinical history, chest radiography (X-rays), transthoracic ultrasound, and contrast-enhanced computed tomography (CT) or magnetic resonance imaging (MRI) Patients aged 18 to 65 years Eligible for AAD surgery
Exclusion criteria
Have coronary heart disease, heart failure, severe cardiac tamponade, unstable hemodynamics, severe nervous system abnormalities, clinically apparent malperfusion\[9\] including lower limb, cerebral, coronary and renal malperfusion, and visceral ischemia, sever hepatic and renal abnormalities Have undergone any of the cardiac and thoracic surgeries Are unlikely to be able to perform the required clinical assessment tasks Have significant cognitive impairment or language issues Are unable to provide consent with regard to their participation in the study Prescribed with non-steroidal anti-inflammatory drugs or corticosteroids before or after admission
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| oxygenation index | perioperative period |
Secondary
| Measure | Time frame |
|---|---|
| alterations in cytokine and ROS in the perioperative period | perioperative period |
| extubation time | perioperative period |
| complications of vital organs | perioperative period |
Countries
China
Contacts
Primary ContactWeiping Weiping, master
Outcome results
None listed