Ischemic Heart Disease, Kidney Disease, Chronic
Conditions
Brief summary
There is a pressing need to find effective strategies for the prevention of contrast induced nephropathy in patients with advanced renal dysfunction. The current study was designed to assess the efficacy of a new protocol for preventing contrast induced nephropathy in patients with advanced renal dysfunction undergoing coronary interventions
Interventions
PROCEDUREPercutaneous coronary intervention
Patients planned for coronary angiography or percutaneous coronary intervention will be managed using a protocol that allows us to use minimal volumes of contrast dye
Sponsors
Meir Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
Patients with estimated glomerular filtration rate\<45ml/min undergoing coronary angiography due to one of the following indications in accordance with the 2014 guidelines: 1. Elective coronary angiography due to symptoms suggestive for angina with a positive non-invasive ischemia assessment of ≥10% of left ventricle. 2. Non ST-elevation acute coronary syndrome with a GRACE score\>110
Exclusion criteria
* Patients on dialysis or those planned for dialysis in the next 3 months. * Patients with ST-elevation myocardial infarction * No symptoms or signs of heart failure * Treatment with IV diuretics during the 48 hours prior to enrolment * Patients with acute renal failure (Creatinine raise of at least 0.3mg/dl from )baseline * Patients post coronary artery bypass surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in glomerular filtration rate following coronary angiography or intervention | 24 and 48 hours post procedure | Significant changes are defined as a reduction ≥25% in glomerular filtration rate |
Countries
Israel
Outcome results
None listed