Breast Cancer, Anxiety, Depression
Conditions
Keywords
Anxiety, Depression, Exercise, Breast Cancer, Biopsy, Screening, Diagnosis
Brief summary
The breast cancer screening and diagnostic period is associated with heightened symptoms of anxiety and depression. Physical exercise has been found to effectively decrease these symptoms in healthy and diseased populations. This study aims to determine if a pre treatment exercise intervention can minimize symptoms of anxiety and depression in women undergoing screening for breast cancer.
Detailed description
The breast cancer diagnostic process is associated with anxiety and depression. Physical exercise has emerged as an attractive non-pharmacologic approach to mitigating the psychological and physical sequelae of breast cancer and its treatments, however pre treatment interventions are not integrated into current practice. This study aims to determine the effectiveness and feasibility of a pre treatment exercise intervention in attenuating levels of anxiety and depression following breast biopsy and throughout the diagnostic period.
Interventions
BEHAVIORALModerate intensity exercise training
6 weeks of moderate intensity exercise training (50 - 75% of heart rate reserve). Sessions are facility and home based and include cardiovascular warm-up, cardiovascular training, muscular conditioning, and flexibility exercises.
BEHAVIORALSelf Management of exercise
In addition to the 6 week exercise program (refer to Exercise Treatment Group), participants randomly assigned to the Self Management Group will learn strategies for the self management of exercise.
Sponsors
University of Western Ontario, Canada
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 69 Years
Healthy volunteers
No
Inclusion criteria
* undergoing breast biopsy at St. Joseph's Health Care, London Ontario * minimum BI-RADS 4a * physically inactive
Exclusion criteria
* meeting Health Canada Guidelines for Physical Activity for past 6 months * medical contraindications to exercise * unable to participate in moderate intensity exercise program
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Symptoms of anxiety will be assessed using patient reported anxiety inventory | Change in baseline (within 1 week of breast biopsy) at Week 3 and at Week 6 | Spielberger State-Trait Anxiety Inventory - State Form (STAI; Spielberger, Gorsuch, & Lushene, 1970). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Exercise behaviour will be assessed using a patient reported inventory | Within 1 week of breast biopsy, Week 3, Week 6 | Leisure Time Exercise Questionnaire (Godin & Shephard, 1985) |
| Body composition: Dual X-Ray Absorptiometry scan (GE Lunar iDXA) | Baseline (within 1 week of breast biopsy), Week 6 | — |
| Symptoms of subclinical depression will be assessed using a patient reported inventory | Within 1 week of breast biopsy, Week 3, Week 6 | Centre for Epidemiologic Studies-Depression Scale (CES-D; Radloff, 1977). |
| Optimism: patient reported inventory assessing dispositional optimism | Baseline (within 1 week of core breast biopsy) | Life Orientation Test-Revised (LOT-R; Scheier, Carver, & Bridges, 1994). |
| Symptoms of dispositional anxiety will be assessed using patient reported anxiety inventory | Within 1 week of breast biopsy | STAI - Trait Form |
| Self Efficacy: patient reported inventory assessing efficacy for self management of exercise | 1 week post breast biopsy, Week 3, Week 6 | — |
Countries
Canada
Outcome results
None listed