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The Effect of Informative Letters on the Prescription and Receipt of Seroquel

The Effect of Informative Letters on the Prescription and Receipt of Seroquel

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02467933
Enrollment
5055
Registered
2015-06-10
Start date
2015-04-30
Completion date
2017-04-30
Last updated
2021-08-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Centers for Medicare and Medicaid Services (U.S.), Delivery of Health Care, Economics, Fraud, Health Expenditures

Brief summary

Abusive prescribing exposes patients to unnecessary health risks and results in wasteful public expenditures. This study will evaluate an innovative approach to fighting abusive prescription: sending letters to suspected inappropriate prescribers warning them that they are outliers compared to their peers and have been flagged for review. The study will target high prescribers of Seroquel (Quetiapine), an atypical antipsychotic. Using claims data, the investigators will assess the effect of the letters on prescribing of Seroquel, receipt of Seroquel by patients, substitution behavior by prescribers and patients, and health outcomes of patients.

Interventions

OTHERPlacebo letter

The placebo letter describes a new rule in Medicare that requires prescribers to enroll in Medicare

OTHERInitial Informative letter

The intervention is a letter that describes the Seroquel prescribing activity of the individual in comparison to a peer group of similar prescribers. It highlights the fact that the prescriber's activity is highly unlike her peers.

OTHERFollowup Informative Letter

The followup informative letter is identical to the initial informative letter except it provides an update on more recent prescribing rather than a description of earlier prescribing.

Sponsors

Centers for Medicare and Medicaid Services
CollaboratorFED
General Services Administration (GSA)
CollaboratorFED
Abdul Latif Jameel Poverty Action Lab
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE

Eligibility

Sex/Gender
ALL
Healthy volunteers
Yes

Inclusion criteria

* General care practitioner * Outlier with respect to the count of Seroquel prescription drug treatments relative to peer group of prescribers in 2013 and 2014 * Outlier with respect to the count of Seroquel 30-day equivalent prescription drug treatments relative to peer group of prescribers in 2013 and 2014

Exclusion criteria

* Deceased

Design outcomes

Primary

MeasureTime frameDescription
30-day equivalent prescribing of Seroquel treatments9 monthsThe prescribing of Seroquel over the 9 months following the initial sending of the letters. Prescribing is defined as the total days supply of Seroquel attributed to the prescriber, expressed in 30-day equivalents i.e. divided by 30.

Secondary

MeasureTime frame
30-day equivalent prescribing of Seroquel treatments3 months

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 23, 2026