CRPS
Conditions
Keywords
CRPS, intervention, multimodal
Brief summary
A ten week open label study intervention to evaluate the outcome for a psychological intervention combined with physiotherapy and medication with memantine-morphine in 10 CRPS patients.
Detailed description
Ten CRPS I patients attended an intervention for 10 weeks. First, the medication was started with morphine 10mg adding gradually to 30 mg per day. Then, in addition to morphine, memantine 5 mg was started adding the dose gradually up to 40 mg per day if tolerated. Physiotherapy and psychological intervention were mostly carried out in a weekly group gathering with home exercises that were recorded to a diary. Psychological and physiotherapy interventions lasted for eight weeks. A neurological examination was done before and after the intervention as well as a separate physiotherapist examination of the hands. Patients filled out questionnaires of mood, quality of life, pain, and CRPS descriptions before and after the intervention.
Interventions
DRUGMorphine, memantine
Morphine up to 30 mg per day orally and memantine up to 40 mg per day orally if tolerated for 10 weeks.
BEHAVIORALPsychological intervention
To help patients shift perspective from pain and CRPS-symptoms, to increase body awareness, to create vivid imagenary, to increase the use of a CRPS hand with mindfulness exposure exercises, to increase flexibility in behavioral repertoire, to explore the fusion of emotions, automatic cognitions and learned responses and to help patients to integrate new skills in their lives.
Graded motor imagenary with group and individual weekly sessions with daily practices at home.
Sponsors
Helsinki University Central Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* CRPS type 1 for at least 6 months, * pain NRS 4 or more
Exclusion criteria
* major psychiatric or neurological disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Direction of change in patient reported CRPS symptom discriptors | Three months | Reports of CRPS symptoms |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Direction of change in motor parameters | Three months | Measurements of strength of the hand, the active range of motion in the hand/arm, 9HPT, DASH questionnaire |
| Direction of change in psychological parameters | Three months | Patient scores in BDI, PASS-20, CPAQ |
| Direction of change in quality of life | Three months | Patient scores in 15D |
Countries
Finland
Outcome results
None listed