Bacterial Meningitis
Conditions
Brief summary
The purpose of this study is to determine whether deficiency of Vitamin D has association with outcomes of children with bacterial meningitis.
Detailed description
Vitamin D deficiency has been proved in serious diseases patients, including patients in shock, however, few study have been done about association between deficiency of Vitamin D and outcomes of children with bacterial meningitis. in our study, we will observe incidence of complication and severity of complication between patients who have different Vitamin D status.
Interventions
None listed
Sponsors
Gang Liu
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Months to 18 Years
Healthy volunteers
No
Inclusion criteria
* Probable bacterial meningitis patients: Clinical manifestation (Any person with sudden onset of fever (\> 38.5 °C rectal or 38.0 °C axillary) and one of the following signs: neck stiffness, altered consciousness or other meningeal sign) with cerebrospinal fluid examination showing at least one of the following: A. turbid appearance; B.leukocytosis (\> 100 cells/mm3); C.leukocytosis (10-100 cells/ mm3) AND either an elevated protein (\> 100 mg/dl) or decreased glucose (\< 40 mg/dl) * Confirmed bacterial meningitis patients: A case that is laboratory-confirmed by growing (i.e. culturing) or identifying (i.e. by Gram stain or antigen detection methods) a bacterial pathogen (Hib, pneumococcus or meningococcus) in the cerebrospinal fluid or from the blood in a child with a clinical syndrome consistent with bacterial meningitis
Exclusion criteria
* Congenital immunodeficiency patients * HIV patients * Patients with corticosteroid treatment for long time * Patients with disorders in adrenal gland and pituitary gland and hypothalamus * Patients with tuberculosis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| vitamin d level change | change in serum vitamin d level from baseline to 28 days after initial hospitalization | Serum vitamin d level will be detected in the first day of hospitalization and twenty-eighth day of hospitalization, no vitamin d supplementation during this time |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Clinical assessment of disease severity with Glasgow score | 1 day | Disease severity will be assessed with Glasgow score in the first day of hospitalization |
| Clinical assessment of disease severity with pediatric critical illness score | 1 day | Disease severity will be assessed with pediatric critical illness score in the first day of hospitalization |
| Clinical assessment of disease severity with cerebrospinal fluid examination | 1 day | Cerebrospinal fluid examination including white blood cell count, protein concentration and glucose concentration in cerebrospinal fluid |
| Assessment of complications | 1 day | Assessment of complications include whether patients have complications, which kind of complication patients suffered, and whether needing surgical therapy. |
Outcome results
None listed