Gum Arabic as Fetal Hemoglobin Agent in Sickle Cell Anemia

Conditions

Sickle Cell Anemia

Brief summary

The purpose of this study is to determine whether Gum Arabic is effective as fetal hemoglobin inducing agent for sickle cell anemia patients.

Detailed description

: High level of fetal haemoglobin (Hb F) decreases sickle cell anaemia (SCA) severity and leads to improved survival. Butyrate proved to increase HbF production in vivo and in vitro studies. Nonetheless, its short half-life limited its utilization in clinical practice. Gum Arabic (GA) is edible, dried, gummy exudate from Acacia Senegal tree. GA fermentation by colonic bacteria increases serum butyrate concentrations. The investigators hypothesized regular intake of GA will increase serum butyrate level. The latter will induce fetal hemoglobin production and ameliorate patients' symptoms. 47 patients hemoglobin SS aged 5-42 years, on regular follow up in Military hospital were recruited from April 2014 to January 2015 Patients received dose of G A 30g/day for 12 weeks. Hb F, complete blood count and Erythropoietin level were measured. The main outcome of interest was the level of HbF after 12 weeks.

Kaddam LA, Kaddam AS.

2020-03-188 citations

10.1186/s13104-020-05016-2

Acacia Senegal (Gum Arabic) Supplementation Modulate Lipid Profile and Ameliorated Dyslipidemia among Sickle Cell Anemia Patients

Lamis Kaddam, Imad Fadl-Elmula, Omer Ali Eisawi, Haydar Awad Abdelrazig, Amal Saeed

Journal of Lipids2019-06-1817 citations

10.1155/2019/3129461

Biochemical effects and safety of Gum arabic (<i>Acacia Senegal</i>) supplementation in patients with sickle cell anemia.

Kaddam LA, Fdl-Elmula I, Eisawi OA, Abdelrazig HA, Elnimeiri MK, Saeed AM.

2019-03-218 citations

10.5045/br.2019.54.1.31

Gum Arabic as novel anti-oxidant agent in sickle cell anemia, phase II trial

Lamis Kaddam, Imad Fadl-Elmula, Omer Ali Eisawi, Haydar Awad Abdelrazig, Mohammed Abdelraman Salih et al. (7 authors)

BMC Hematology2017-03-1668 citations

10.1186/s12878-017-0075-y

Gum Arabic as fetal hemoglobin inducing agent in sickle cell anemia; in vivo study

Lamis Kaddam, Imad FdleAlmula, Omer Ali Eisawi, Haydar Awad Abdelrazig, Mustafa Khidir Mustafa Elnimeiri et al. (7 authors)

BMC Hematology2015-12-0133 citations

10.1186/s12878-015-0040-6

Interventions

DIETARY_SUPPLEMENTGum Arabic

oral ingestion of 30 gram every day for 12 weeks

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

5 Years to 50 Years

Healthy volunteers

No

Inclusion criteria

1. over 5 year old 2. less t5han 50 3. diagnosed with homozygous sickle cell anemia by Hb electrophoresis

Exclusion criteria

1\. patients received blood transfusion within the last three months or admitted to the hospital within 2 weeks because of Sickle cell anemia -related events or crisis.

Design outcomes

Primary

Measure	Time frame	Description
The primary endpoint of the study will be the level of fetal hemoglobin after three months	12 weeks	fetal hemoglobin will be measured each month for three months

Countries

Sudan

Outcome results

None listed