Healthy Children
Conditions
Brief summary
The primary objective of this trial is to identify how much protein is required at breakfast to promote positive whole body protein balance over the following 9h period.
Detailed description
This study will be the first to establish the role of eating protein at breakfast on whole body protein balance in healthy children.
Interventions
OTHERProtein-based beverage
protein-based beverage
Sponsors
Société des Produits Nestlé (SPN)
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
7 Years to 10 Years
Healthy volunteers
Yes
Inclusion criteria
* Aged between 7-12 years of age * Healthy and recreationally physically active (obtaining a 3- day average moderate/vigorous physical activity of at least 30 min/day) * Body mass at ≥10th percentile for 7 year olds and ≤85th percentile for 12 year olds. Values based upon 2000 CDC Growth Charts for the United States * Having obtained his/her informed assent * Having obtained his/her consent from parent or legal guardian * Being able to communicate in local language * Have a habitual daily protein consumption of between 1.6 g/kg and 2.4 g/kg/bw
Exclusion criteria
* Self-report on regular medication impacting the metabolism, such as corticoids, hormone (e.g thyroid, adrenal) treatment, or medication against diabetes or against hypercholesterolemia or hypertriglyceridemia * Self-reported history of metabolic, hepatic or renal disease * Self-reported allergy to milk proteins (e.g., whey or casein) or intolerance to any food ingredients to be used in the study products and meals * Within 1.5 years of estimated age of peak height velocity (PHV) * Special diet or weight loss program (e.g Atkins diet) * Consuming breakfast containing more than 21g of protein on each day of the 3-d screening period * Subject who cannot be expected to comply with the study procedures, including unwillingness to consume study product and meals * Currently participating or having participated in another nutritional-clinical trial during the last 2 months prior to the beginning of this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Whole body protein balance (g protein/9 hours) by nitrogen balance technique | 9 hours following ingestion of investigational product |
Secondary
| Measure | Time frame |
|---|---|
| Whole body protein balance (g protein/24 hours) by nitrogen balance technique | 24 hours following ingestion of investigational product |
Countries
Canada
Outcome results
None listed