Diabetes, Obesity
Conditions
Keywords
Satiety, Food intake, Breakfast cereals/snacks, Postprandial glycemia
Brief summary
The goal of the proposed research is to investigate the effects of novel snack products differing in macronutrient composition, fibre and sugar content on post-prandial glycemia and short-term appetite control in healthy adults.
Interventions
OTHERDietary intervention
All arms are given to all participants, in a randomized order
Sponsors
General Mills
University of Toronto
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy, non-smoking individuals aged 18-55 years with a body mass index of 20.0-29.9 kg/m2
Exclusion criteria
* Smokers, individuals with diabetes or other cardiometabolic diseases, persons who suffer from gastrointestinal disorders or have had gastric surgery, or people who regularly use bulk laxatives * Women with irregular menstruation or who use hormonal contraceptives or hormone replacement therapy * Individuals who regularly skip breakfast, have allergies to any of the test food ingredients, or who follow a restrictive diet
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Food intake | 120 minutes | Food intake (kCal) is assessed 120 min after consumption of the treatments, using an ad libitum pizza lunch design. Participants are asked to eat, during a 20-min period, until feeling comfortably full |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Perceived satiety | 120 minutes | Satiety scores (mm) are assessed using 100-mm Motivation to Eat visual analog scale questionnaires. A composite score of the four appetite questions, including Desire to Eat, Hunger, Fullness and Prospective Food Consumption, in the Motivation to Eat visual analog scale is calculated to obtain the average appetite score for statistical analysis |
| Blood glucose | 0 to 120 min (pre-ad libitum lunch) and 140 to 260 min (post-ad libitum lunch) after consumption of treatments | Blood glucose (mmol/L) is measured using finger prick capillary blood samples |
| Blood insulin | 0 to 120 min (pre-ad libitum lunch) and 140 to 260 min (post-ad libitum lunch) after consumption of treatments | Blood insulin (μU/mL) is measured using finger prick capillary blood samples |
Other
| Measure | Time frame | Description |
|---|---|---|
| Food Recall | 24 hours | Participants are asked to complete a 24-hour Food Recall starting at dinner the night before each study session and ending at dinner the day of that session. |
Countries
Canada
Outcome results
None listed