The Use of Point-of-Care Ultrasound in the Diagnosis of Acute Infectious Mononucleosis in the Emergency Department

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02463669

Enrollment

200

Registered

2015-06-04

Start date

2016-04-30

Completion date

2020-10-04

Last updated

2020-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infectious Mononucleosis, Splenomegaly

Keywords

Point-of-care ultrasound

Brief summary

The purpose of this study is to determine if splenomegaly on point-of-care ultrasound (POCUS) is an accurate and user-friendly surrogate to the heterophile antibody test and Epstein-Barr Virus (EBV) serologies to diagnose acute mononucleosis infection in patients presenting with sore throat to the Emergency Department (ED).

Detailed description

The investigators seek to determine whether the presence of splenomegaly on POCUS can accurately diagnose acute infectious mononucleosis in symptomatic ED patients, and determine the feasibility of performing point-of-care ultrasound for splenomegaly by emergency physicians in the emergency department setting.

Interventions

DEVICEPoint-of-care ultrasound

Enrolled patients will undergo POCUS of the spleen by the treating emergency physician (resident, fellow or attending). Canadian Emergency Ultrasound Society (CEUS) certified residents, fellows and attending physicians will conduct the bedside ultrasonography after receiving specific training for the purposes of this study. The spleen will be assessed using a curved 2-6 Megahertz (MHz) transducer with the participant in the supine position. The cranio-caudal splenic length will be measured and its maximum dimension will be recorded on the standardized study data sheet.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

10 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* Patients aged between 10 and 35 year-old presenting to the ED with suspected acute infectious mononucleosis

Exclusion criteria

* Chronic infectious disorders (eg. tuberculosis, malaria, HIV, syphilis) * Inflammatory disorders (eg. sarcoidosis, amyloidosis, systemic lupus erythematosus, Felty syndrome) * Proliferative disorders (eg. lymphoma, leukemia, essential thrombocytopenia, polycythemia vera) * Congestive disorders (eg: cirrhosis, portal hypertension, right heart failure, congenital heart disease) * Chronic haemolytic anemia (eg. sickle cell, thalassemia, hereditary spherocytosis) * Storage diseases (eg. Gaucher, Niemann-Pick) * Splenectomy * Inability to give informed consent

Design outcomes

Primary

Measure	Time frame	Description
Presence of splenomegaly (maximal splenic cranio-caudal length) on point-of-care ultrasound	12 months	Splenomegaly is defined as a splenic length of \> 11.5 centimetres (cm) for 10-12 year-old patients, \> 12 cm for 12-15 year-old patients, \> 12 cm for 15-35 year-old female patients, and \> 13 cm for 15-35 year-old male patients.

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026