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Porous and Non-porous Bone Grafts in Intra-bony Periodontal Defects

Comparative Evaluation of Porous and Non Porous Variants of Bioactive Glass in the Treatment of Periodontal Intrabony Defects: A Cone Beam Computed Tomography Analysis

Status
Completed
Phases
Phase 2Phase 3
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02463006
Enrollment
10
Registered
2015-06-04
Start date
2014-01-31
Completion date
2015-05-31
Last updated
2015-06-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontal Disease

Brief summary

Till date, no study has been reported in the literature where porous bioactive glass was used for the management of periodontal osseous defects. In this context, the present study is designed to assess the efficacy of the porous variant of bioactive glass and compare with that of nonporous variant using cone beam computed tomography.

Detailed description

OBJECTIVES: 1. To evaluate clinically the periodontal healing with Porous variant of Bioactive Glass placed in the intra bony defects at an interval of 6 months. 2. To evaluate clinically the periodontal healing with Non Porous variant of Bioactive Glass placed in the intra bony defects at an interval of 6 months. 3. To evaluate the radiographic changes in the intra bony defect grafted with Porous variant of Bioactive Glass at baseline and an interval of 6 months. 4. To evaluate the radiographic changes in the intra bony defect grafted with Non Porous variant of Bioactive Glass at baseline and an interval of 6 months. 5. To compare clinically soft tissue healing for sites grafted with Porous variant of Bioactive Glass and sites grafted with Non Porous variant of Bioactive Glass in the treatment of periodontal intra bony defects at an interval of 6 months. 6. To compare the radiographic changes for sites grafted with Porous variant and sites grafted with Non Porous of Bioactive Glass in the treatment of periodontal intra bony defects at an interval of 6 months.

Interventions

DRUGPorous variant of Bioactive Glass.

Flap surgery with Porous variant of Bioactive Glass.

DRUGNon porous variant of Bioactive Glass.

Flap surgery with non-Porous variant of Bioactive Glass.

Sponsors

Dr. D. Y. Patil Dental College & Hospital
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
No

Inclusion criteria

* INCLUSION CRITERIA 1. Age: 18-55 years. 2. Probing Depth \>5mm.

Exclusion criteria

*

Design outcomes

Primary

MeasureTime frame
Change in relative attachment loss6 months

Secondary

MeasureTime frame
Change in probing depth6 months
Change in plaque index6 months

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026