Mild Cognitive Impairment
Conditions
Keywords
Mild cognitive impairment, Memory training, Randomized controlled study
Brief summary
This study sought to investigate the changes in objective memory performance (including immediate recall and delayed recall), subjective memory complaints and degree of depression in older adults with mild cognitive impairment after Virtual interactive memory training (VIMT).
Detailed description
This double-blind randomized controlled study has a 2-arm parallel group design. All subjects will be randomized by the block randomization, into intervention group (Virtual interactive memory training, VIMT), or active control group (Passive information activities, PIA). Training sessions of the VIMT group are 45 minutes/day, 3 days/week, for 12 weeks (36 sessions each). The training of PIA group is the same as VIMT group. We constructed a rigorous VIMT program adhering to the Consolidated Standards of Reporting Trials (CONSORT) reporting guidelines. The investigators expect to determine the improvement in memory function and degree of depression of older adults with mild cognitive impairment after using the VIMT.
Interventions
BEHAVIORALVirtual interactive memory training
Training sessions of the VIMT group are divided into initial training and booster training. Each training session is 45 minutes/day, 3 sessions/week, for 12 weeks for both initial training and booster training (36 sessions each). The training content of the four memory training include: (1) spatial encoding memory training task, (2) updating-spatial memory training task, (3) updating-visual memory training task, and (4) rehearsal-visuospatial memory training task.
BEHAVIORALPassive information activities
The active control group (Passive information activities) only accepts the initial training phase, which training content of the two types to include: (1) listening to audio books, and (2) reading online newspaper.
Sponsors
Ministry of Science and Technology, Taiwan
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1. Participants must endorse at least two items from a list of frequent subjective memory complaints by patient and/or an informant 2. Objective memory impairment on neuropsychological tests of memory 1.5 SD or more below age/education norms 3. Clinical neurologic examination by the Mini-Mental State Examination (MMSE) score of 24 or higher, and cut-off score of 23/24 on the Montreal Cognitive Assessment (MoCA) 4. No impairment in personal activities of daily living (P-ADL) as determined by clinical interview with participant and family
Exclusion criteria
1. The clinical diagnosis of dementia was based on the DSM-IV-TR 2. Active in another cognitive or memory-related training in the past year 3. Comorbid medical conditions that would predispose them to imminent functional decline or cognitive impairment 4. A diagnosis of major neurological or psychiatric illness history and/or behavioral problems that would sufficiently impair performance to make participation impossible 5. Severe losses in vision, hearing, or communicative ability
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in objective memory performance as measured by the Chinese version of the Wechsler Memory Scale-III (WMS-III). | Change from baseline in objective memory performance at Immediate post-test, 3 months, 6 months and one year after intervention. |
Secondary
| Measure | Time frame |
|---|---|
| Change in subjective memory complaints as measured by the Multifactorial Memory Questionnaire (MMQ). | Change from baseline in subjective memory complaints at Immediate post-test, 3 months, 6 months and one year after intervention. |
Countries
Taiwan
Outcome results
None listed