Chronic Periodontitis
Conditions
Keywords
alendronate, metformin
Brief summary
This is a 9 month randomised controlled clinical comparing the clinical efficacy of 1%metformin and 1%alendronate in chronic periodontitis subjects.
Detailed description
ABSTRACT Background: Since Metformin (MF) induces osteoblast growth and differentiation while Alendronate (ALN) act as an antiosteolytic agent. The aim of the present study is to evaluate and compare the efficacy of 1% ALN and 1% MF gel as a local drug delivery system in adjunct to scaling and root planing (SRP) for the treatment of intrabony defects in patients with chronic periodontitis. Methods: The study had 3 groups comprising of ninety subjects, divided into three groups 1% MF with SRP, 1% ALN with SRP and placebo gel with SRP. Clinical parameters (plaque index (PI), modified sulcus bleeding index (mSBI), probing pocket depth (PPD), and clinical attachment level (CAL) were recorded at baseline, 3, 6 and 9 months. Radiographic parameters intrabony defect depth (IBD) and defect depth reduction (DDR%) was calculated on standardized radiographs by using image analysis software at 6 and 9 months
Interventions
After SRP, placebo gel was delivered subgingivally into the pocket
DRUGSRP plus Alendronate gel
Alendronate (ALN) After SRP, ALN gel was delivered subgingivally into the pocket
DRUGSRP plus Metformin gel
Metformin (MF) After SRP, MF gel was delivered subgingivally into the pocket
Sponsors
Government Dental College and Research Institute, Bangalore
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
25 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* All the subjects were systemically healthy * subjects with sites having CAL ≥ 3 mm, PPD ≥ 5 mm, * vertical bone loss ≥ 3 mm on intraoral periapical radiographs (IOPA) and * subjects with no history of periodontal intervention in the last 6 months.
Exclusion criteria
* patients with systemic diseases like cardiovascular disease * diabetes or HIV infection or on medications like corticosteroids which may impede the healing in periodontal tissues. * pregnant/lactating females * tobacco users * alcoholics * patients with unsatisfactory oral hygiene (plaque index greater than 1.5) * teeth having gingival recession, caries involving pulp, intrabony defect present interproximally, grade 2/3 mobility * Furthermore, patients allergic to Metformin and alendronate or those taking Metformin and alendronate systemically were excluded.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| bone fill | baseline to 9 months | amount of bone fill from baseline to 9 months |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Relative vertical clinical attachment level | baseline to 9 months | change in Relative vertical clinical attachment level baseline to 9 months |
| probing depth | baseline to 9 months | change in probing depth from baseline to 9 months |
Outcome results
None listed