Periodontal Diseases
Conditions
Keywords
Scaling and root planning, C-reactive protein
Brief summary
This study has compared quadrant scaling and root planing (Q-SRP) versus intensive treatment performed within 24 hours (FM-SRP) in terms of acute phase responses following treatment of periodontal disease. The primary aim was to compare the differences in CRP acute increase following FM-SRP versus Q-SRP therapy (24 hours after therapy). Secondary outcomes included changes in a broad array of inflammatory and endothelial injury markers between groups. Patients were randomly assigned to either FM-SRP and Q-SRP. Data indicated that non-surgical periodontal therapy performed within 24 hours induced greater perturbations of systemic inflammation compared to conventional treatment.
Detailed description
Aim. A moderate acute-phase response occurs 24 hours following full-mouth non-surgical treatment (FM-SRP). Aim of this study will be to compare quadrant scaling (Q-SRP) versus FM-SRP in terms of systemic acute (24 hours) and medium-term (3 months) inflammation. Material & Methods. 38 periodontitis-affected subjects will be randomly allocated to FM-SRP or Q-SRP after a baseline visit. Periodontal and anthropometric parameters, such as systolic and diastolic bood pressure, BMI and temperature, will be collected at baseline and 3 months. Serum samples will be drawn at baseline, 1, 7 and 90 days after treatment. High sensitivity assays for a broad array of inflammatory (PCR, IL-6, TNF-alpha) and endothelial assays will be performed.
Interventions
PROCEDUREScaling & Root Planing
It consists in the non-surgical debridement of the sub gingival area affected by periodontal disease
Sponsors
Eastman Dental Insitute and Hospital
University of Pisa
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Patients presenting with probing pocket depths (PPD) ≥5 mm, * bleeding on probing on at least 25% of their total sites * documented radiographic alveolar bone loss
Exclusion criteria
* age earlier than 18 and older than 70 years; * pregnant or lactating females; * females using contraceptive methods; * reported diagnosis of any systemic illnesses including cardiovascular, renal and liver diseases; * any pharmacological treatment within the 3 months before the beginning of the study; * PT in the previous 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| C reactive Protein | 24 Hours |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Tumor Necrosis Factor - alpha | 24 Hours, 7 days, 90 days | — |
| Interleukin - 6 | 24 Hours, 7 days, 90 days | — |
| periodontal pocket depth (PPD) | 90 days | mean in mm |
| C reactive Protein | 7 days, 90 days | — |
| number of pockets > 4 mm | 90 days | number of pockets \> 4 mm |
| Full Mouth Plaque Score | 90 days | presence/absence of dental plaque in percentual values |
| Full Mouth Bleeding Score | 90 days | presence/absence of sites bleeding on probing in percentual values |
| clinical attachment level (CAL) | 90 days | mean in mm |
Outcome results
None listed