Constipation, Guillain-Barre Syndrome
Conditions
Brief summary
Constipation is a common condition among patients with Guillain-Barré Syndrome. It is believed, that the constipation is caused by autonomic neuropathy. However, the severity of the constipation, and its relation to autonomic function have not previously been studied.
Interventions
None listed
Sponsors
University of Aarhus
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 79 Years
Healthy volunteers
No
Inclusion criteria
* Guillain-Barré Syndrome * Ability to swallow the capsules used to assess GITT * Ability to give meaningful informed consent to participate in the study
Exclusion criteria
* Major abdominal disorders * Severe acute comorbidity * Known cancer * Pregnancy * Other known neurological disorder * Use of laxatives one week before inclusion. (Patients will be excluded if medication with laxatives is started during the one week GITT measurement)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gastrointestinal transit time (GITT) [in days] | The measurement takes one week to perform. The investigators aim to start the measurement within one week after diagnosis. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Association between heart rate variability (HRV) and GITT | The first HRV measurement is performed within one week after diagnosis. The second is performed 7 days after the first. | Linear regression with GITT as dependent variable, and high frequency power spectral density analysis of the heart rate (HF) as the independent variable. The mean HF of the first and second HRV measurement is used for this regression. |
Countries
Denmark
Outcome results
None listed