Diabetes, Pre-diabetes
Conditions
Keywords
incretin release
Brief summary
Epidemiological data suggest, that not only sugar-based, but also artificially sweetened soft drinks may play a role in the development of diabetes. Recent studies in animals and humans have shown, that artificial sweeteners (AS) influence metabolic responses after glucose ingestion, possibly alter the intestinal microbiome and even modulate incretin release. However, it is unclear, if these findings are valid for all kinds of AS, as they are chemically different. Furthermore, data on human subjects are sparse and controversial. The investigators will therefore conduct 7 consecutive single oral stimulations with glucose or AS alone or a combination. Three different AS will be tested.
Detailed description
Epidemiological data suggest, that not only sugar-based, but also artificially sweetened soft drinks may play a role in the development of diabetes. Recent studies in animals and humans have shown, that artificial sweeteners (AS) influence metabolic responses after glucose ingestion, possibly alter the intestinal microbiome and even modulate incretin release. However, it is unclear, if these findings are valid for all kinds of AS, as they are chemically different. Up to now, no single study has ever compared metabolic responses to different AS in the same subjects. Furthermore, data on human subjects are sparse and controversial. This is partially explained by different methodical approaches such as intragastral/intraduodenal application of AS, rather than conventional oral consumption. The investigators will therefore conduct 7 consecutive single oral stimulations with glucose or AS alone or a combination. Three different AS will be tested: saccharin, aspartame and sucralose.
Interventions
OTHERoral stimulation glucose
oral stimulation with glucose, AS or glucose+AS in fasted state, blood samples from fasted state up to 120 min post-ingestion
OTHERoral stimulation saccharin
OTHERoral stimulation aspartame
OTHERoral stimulation sucralose
Sponsors
Ludwig-Maximilians - University of Munich
German Institute of Human Nutrition
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy
Exclusion criteria
* metabolic disorders such as diabetes, hypothyroidism, corticoid therapy, heart or lung disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| change in GIP release | 120 mins | comparison between all seven interventions |
| change in GLP-1 release | 120 mins | comparison between all seven interventions |
| change in GLP-2 release | 120 mins | comparison between all seven interventions |
| change in PYY release | 120 mins | comparison between all seven interventions |
| change in insulin release | 120 mins | comparison between all seven interventions |
| change in combined blood levels of glucose and insulin, expressed in calculated indices for insulin secretion | 120 mins | comparison between all seven interventions |
| change in combined blood levels of glucose and insulin, expressed in calculated indices for insulin sensitivity | 120 mins | comparison between all seven interventions |
Countries
Germany
Outcome results
None listed