Diagnostic Performance of Cardiovascular Autonomic Neuropathy
Conditions
Keywords
Bayesian estimation, short-term heart rate variability, cardiovascular autonomic neuropathy, diagnostic performance
Brief summary
This study aimed to evaluate the reference values for the short-term heart rate variable (HRV), estimate the performance of cardiovascular autonomic neuropathy (CAN) diagnostic tests in the absence of a gold standard, and assess CAN prevalence in our cross-sectional dataset.
Detailed description
The CAN prevalence is rapidly growing in all populations worldwide. No document has been reported about normal reference values for CAN using this test in the Chinese population. This study aimed to evaluate the reference values for the short-term HRV in a large cross-sectional dataset, and to estimate sensitivities and specificities of CAN diagnostic tests using the Bayesian approach, in the absence of a gold standard in another independence dataset. Finally, CAN prevalence was estimated in the investigators' cross-sectional dataset. Firstly, the reference the values for the short-term HRV were calculated in the investigators' previous study (including 371 healthy subjects). This study dataset contained 88 subjects who completed both the short-term HRV test and Ewing's test. Simultaneous inferences about the population prevalence and the performance of each diagnostic test were possible using the Bayesian approach without a gold standard.
Interventions
OTHERnot intervention
This is a cross-sectional study for estimation of diagnostic performance.
Sponsors
Huashan Hospital
Shanghai Tongji Hospital, Tongji University School of Medicine
Study design
Observational model
ECOLOGIC_OR_COMMUNITY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
30 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Survey participants with undiagnosed CAN, aged 30-80 years, were included in this study.
Exclusion criteria
* Some subjects were excluded from the study to eliminate potential confounding factors that may have influenced their CA function 11. Briefly, the
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cardiovascular autonomic function evaluate by short-term heart rate variability test | participants will be measured for the duration of outpatient stay, an expected average of two days | Both short-term heart rate variability and Ewing's test measure cardiovascular autonomic function |
| Cardiovascular autonomic function evaluate by Ewing's test | participants will be measured for the duration of outpatient stay, an expected average of two days | Both short-term heart rate variability and Ewing's test measure cardiovascular autonomic function |
Countries
China
Outcome results
None listed