Stroke Volume Variation and Pulse Pressure Variation as Predictors of Fluid Responsiveness During Kidney Transplantation

Utility of Stroke Volume Variation and Pulse Pressure Variation for Predicting Fluid Responsiveness in Chronic Renal Failure Patients Undergoing Kidney Transplantation

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02459470

Enrollment

Registered

2015-06-02

Start date

2012-12-31

Completion date

2013-12-31

Last updated

2015-06-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Kidney Transplantation

Keywords

Fluid Responsiveness, Pulse Pressure Variation, Stroke Volume Variation

Brief summary

The aim pf this prospective study is to investigate the ability of stroke volume variation (SVV) and pulse pressure variation (PPV) to predict fluid responsiveness in patients undergoing kidney transplantation.

Detailed description

Optimal intraoperative fluid management guided by central venous pressure (CVP), a traditional intravascular volume status indicator has been established to improve transplanted graft function during renal transplantation. Recently, stroke volume variation (SVV) and pulse pressure variation (PPV), dynamic preload indices derived from the arterial waveform are increasingly advocated as predictors of fluid responsiveness in anesthetized patients and critically ill patients. However, their usefulness in renal failure patients undergoing renal transplantation has not been investigated. Thus, the aims of this study is to investigate accuracy of SVV and PPV for predicting fluid responsiveness in patients undergoing kidney transplantation.

Interventions

PROCEDUREFluid loading

fluid loading was performed by using 7ml/kg of 6% hydroxyethyl starch within 10 min to all patients

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to 70 Years

Healthy volunteers

Inclusion criteria

\- chronic renal failure patients undergoing renal transplantation

Exclusion criteria

* patients with cardiac arrhythmia * patients with reduced left ventricular function (EF \< 40%) * patients with valvular heart disease * patients intracardiac shunt * patients with pulmonary hypertension * patients with extensive peripheral vascular disease * patients with preoperative use of vasopressors or inotropics

Design outcomes

Primary

Measure	Time frame	Description
stroke volume variation from Flo stroke volume variation from FloTrac/Vigileo system	within 5 minutes after fluid expansion	predictable of stroke volume variation from FloTrac/Vigileo system for fluid responsiveness
pulse pressure variation from philips Intelivue MP70 monitor	within 5 minutes after fluid expansion	predictable of pulse pressure variation from philips Intelivue MP70 monitor for fluid responsiveness

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026