Cancer of Colon, Rectum Cancer
Conditions
Brief summary
We collect prospectively and retrospectively, patients' demographic, pathological, surgical, therapeutic and prognosis informations in a database. After patient's consent to collect tumoural samples of their colorectal cancer after resection. We will then be able to evaluate the impact of HSP110, a chaperon protein, on their prognosis. Other proteins (to be determined) will also be study, after.
Detailed description
To investigate the importance of HSP110DE9 as a prognostic marker for colorectal cancer, we will analyze genotyping fluorescence quantitative RT-PCR and / or immunomarquage the presence of this mutant in a large cohort of patients (more than 2000 patients had or having a colorectal cancer). All patients have been or will be made in general and digestive surgery department at Saint-Antoine hospital. Tumor fragments samples were or will be made on their tumor and keep it in the tumor bank of the Saint-Antoine hospital. All patients reported their no objection to the use of these tumor fragments for research purposes. A database will be built and correlated with the tumor fragments. This project is intended that the constitution of a clinical database including prognostic so that we make discoveries on HSP110DE9 or other molecular biology to discover markers can be correlated with clinical data. In the absence of other studies on the subject, with no real knowledge of the prognostic impact of this mutant, we cannot provide an effective computation. We therefore propose to make a database of 2000 patients retrospectively and prospectively to obtain statistical results valid and powerful.
Interventions
GENETICGenetic analysis on tumor kept in tumor bank
Sponsors
Institut National de la Santé Et de la Recherche Médicale, France
Assistance Publique - Hôpitaux de Paris
Study design
Observational model
COHORT
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All patients undergoing curative colorectal cancer in general and digestive surgery department at Saint-Antoine hospital. * Patients reporting their non-opposition to the use of tissue samples taken from their specimen for research purposes.
Exclusion criteria
* Patients who did not report their non-opposition to the use of tissue samples taken from their specimen for research purposes.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Recurrence free survival and Recurrence free survival after resection of the colon cancer | End of follow up : at least 3 years | 3 years for prospective patients, more for retrospective patients |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Overall survival | End of follow up : at least 3 years | 3 years for prospective patients, more for retrospective patients |
Countries
France
Outcome results
None listed