HIV, Nephrolithiasis
Conditions
Keywords
CALVIH, Renal stone, HIV1, Renal colic, Atazanavir, Crystalluria, Chronic Kidney Disease, Calcium Oxalate
Brief summary
The purpose of this study is to define the cause of renal stones and the risk pattern for recurrence of renal stones episodes (any kind of stones) in HIV1 patients.
Detailed description
This study aims at defining the cause of renal stones and the risk pattern for recurrence of renal stones episodes (any kind of stones) in HIV1 patients. Primary Objective : * Finding the cause of renal stone in HIV patients defined as stone composition if stone is available or more probable pathophysiological mechanism * Risk profile for stone recurrences estimated on risk indices in HIV1 patients Secondary Objective(s) * Identify prevalence of recurrences and describe co-morbidities associated with stone disease * Describe urological management for renal stones in HIV patients * Describe the causes of drug induced renal stones
Interventions
None listed
Sponsors
Corinne Isnard Bagnis
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult male or female HIV1 infected patients willing to participate in the study * Having experienced a renal stone episode within the past six months or living with a renal stone * Able to understand the protocol * Giving oral consent
Exclusion criteria
* CT scan impossible * Follow up impossible over 1 year
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Qualitative assessment of the cause of the renal stone | at 6 months | Qualitative assessment of the cause of the renal stone based on different biological and clinical parameters (biochemical analysis of urines, cristalluria, low dose renal CT, patient history, family history…) |
| Risk profile for recurrence of renal stone | at 12 months | Risk profile for recurrence of renal stone estimated based on plasma and urinary parameters, nutritional profile and drug exposure |
Secondary
| Measure | Time frame |
|---|---|
| Follow up outcome of HIV patients over one year to identify prevalence of recurrences and describe co-morbidities associated with stone disease | up to 12 months |
| Urological management for renal stones in HIV patients | up to 12 months |
| Causes of drug induced renal stones | up to 12 months |
| Number of stone recurrences | at 6 months |
Countries
France
Outcome results
None listed