Acne, Eczema, Healthy, Psoriasis
Conditions
Keywords
Sleep, Skin, Circadian Rhythm
Brief summary
The purpose of this study is to explore the mechanisms behind how sleep quality may affect skin aging, skin integrity and skin disease.
Interventions
None listed
Sponsors
University Hospitals Cleveland Medical Center
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Males or females ages 18 years and above * Capable of giving informed consent * Adults who are either healthy, normal volunteers or those with a skin disease including but not limited to eczema, psoriasis, acne or other inflammatory dermatoses * Fitzpatrick Skin Type I-VI * In good general health * Willing to cooperate with study instructions
Exclusion criteria
* Volunteers 18 years or younger * Any serious medical or physical condition that would cause the subject significant discomfort with study procedures * Women who are pregnant, nursing, or who may become pregnant in the next 3 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Analysis of Sleep Pattern via Actigraphy, Polysomnography & Questionnaires | 7-14 days | The volunteers may be asked to wear a wrist actigraph to measure movement. This watch would be worn for 24 hours per day for 7-14 days. The volunteer may also be asked to fill out questionnaires regarding their sleep patterns. Note: Other methods of assessing sleep patterns may also be used including a portable polysomnogram or a standard, overnight sleep study. |
| Evaluation of skin (both in terms of skin aging and skin disease) | Only once during the study or at specific time points depending on what other procedures are being performed | The volunteers may have their skin evaluated for skin aging using the SCINEXA tool. Volunteers with psoriasis may have their skin evaluated via PASI and/or PGA assessments. Volunteers may have photographs taken to compare clinical appearance with laboratory and research findings. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Sample Analysis (from skin, blood, urine, saliva and hair follicle samples) | Only once during the study or at specific time points depending on what other procedures are being performed | Skin, blood, urine, saliva and hair follicle samples may be collected from some volunteers to look at various markers related to sleep, the circadian rhythm and skin disease. |
| Skin Barrier Recovery (via TEWL measurement) | Only once during the study or at specific time points depending on what other procedures are being performed | Skin barrier recovery via Transepidermal Water Loss (TEWL) measurement may be assessed in some volunteers. |
| MED Testing & Recovery from UV-induced erythema | 24 hours | MED Testing & Recovery from UV-induced erythema may be assessed in some volunteers. |
Countries
United States
Outcome results
None listed