Metabolic Diseases
Conditions
Brief summary
The study will investigate if consumption of amino acid mixtures results a change in glycemic response of carbohydrate (white rice) and insulinemic response at different doses and timing (before consumption of carbohydrate).
Detailed description
Healthy male subjects will be served with amino acid mixtures in combinations of two doses and three time points along with white rice as control. The combinations were either low or high levels of amino acid mixtures. This was consumed together or 15 min, 30 min before consumption of white rice. Postprandial blood glucose and plasma insulin concentrations were measured at fasting and every 15 min after consumption of treatment meal until 60 min after the consumption of white rice. Subsequent blood sample were taken at 30 min interval until 210min. The glucose and insulin in the blood will be analysed.
Interventions
OTHERRice and Amino Acid mixtures
Rice and amino acid mixture
Sponsors
Cerebos Asia Pacific Pte Ltd
Singapore Institute of Food and Biotechnology Innovation
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
21 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Male * Chinese ethnicity * Age between 21-50 years * Body mass index (BMI) between 18-24.9 kg/m2 * Waist circumference ≤ 90 cm for men * Normal blood pressure (\<120/80 mmHg) * Fasting blood glucose \< 6 mmol/L
Exclusion criteria
* dislike the consumption of Essence of Chicken * participating in competitive sports * allergic to amino acids and rice * metabolic diseases (such as diabetes, hypertension and the metabolic syndromes) * Glucose-6-Phosphate-Dehydrogenase (G6PD) Deficiency * on prescription medication * smokers
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Glycemic response | 210 minutes post consumption of carbohydrate | Blood glucose will be assessed via finger prick during fasting and every 15 minutes for the first 60 min after the consumption white rice and subsequently every 30 min interval until 210 min |
| Insulinemic response | 210 minutes post consumption of carbohydrate | Plasma insulin will be assessed via finger prick during fasting and every 15 minutes for the first 60 min after the consumption white rice and subsequently every 30 min interval until 210 min |
Outcome results
None listed