Schizophrenia
Conditions
Brief summary
This study plans to learn more about how common drugs prescribed to individuals with schizophrenia contribute to weight gain, as well as how exercise and diet impact appetite and the brain's response to food. In this study, the investigators will be evaluating how participants' brains respond to food images as well as asking questions about their food preferences and intake and clinical symptoms. The investigators may also ask participants to complete an exercise or diet intervention to see how this changes brain responses or food preferences.
Interventions
BEHAVIORALExercise
BEHAVIORALDiet
Sponsors
National Institute of Mental Health (NIMH)
National Center for Advancing Translational Sciences (NCATS)
University of Colorado, Denver
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
21 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosis of schizophrenia or schizoaffective disorder * Between 21 and 70 years of age * Currently prescribed either olanzapine, risperidone, clozapine, or haloperidol, OR not currently being treated with any neuroleptic medications * Weight stable within 5 percent for the last 6 months
Exclusion criteria
* Pregnancy * Substance abuse * Significant endocrine/metabolic disease (e.g., uncontrolled hypertension, severe hypertriglyceridemia) * MRI-specific
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Neuronal response to visual food cues | 14 weeks | Neuronal response (insula) while viewing visual food cues |
| Resting-state neuronal response | 14 weeks | Neuronal response (default mode network) during rest |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Appetite Rating on a visual analogue scale (VAS) | 14 weeks | Participants will be asked to rate their hunger via Hunger ratings on a VAS |
| Fasting leptin | 14 weeks | Fasting blood levels of leptin |
| Fasting ghrelin | 14 weeks | Fasting blood levels of ghrelin |
Countries
United States
Contacts
Primary ContactKristina T Legget, Ph.D.
Outcome results
None listed