Underdosing of Unspecified General Anesthetics
Conditions
Keywords
Remifentanil, Intubation, Children
Brief summary
Introduction: remifentanil's optimal dose for children intubation without neuromuscular blockade is unknown. Method: phase IV adaptative trial using Dixon's up-and-down method for modeling remifentanil's dose-response curve for adequate intubation conditions as defined by previous studies.
Detailed description
Introduction: remifentanil's optimal dose for children intubation without neuromuscular blockade is unknown. Method: phase IV adaptative trial using Dixon's up-and-down method for modeling remifentanil's dose-response curve for adequate intubation conditions as defined by previous studies. Remifentanil doses starting from 2mg/kg will be infused before intubation. When a success occurs next patient's dose will be decreased by 0.25mg/kg/h. When a success does not occur the next patient's dose will be increased by 0.25mg/kg/h. Intubation will be considered adequate if patient does not cough, does not move, if vocal cords are open, if larigocsocpic Cormack grade I or II.
Interventions
DRUGRemifentanil
Remifentanil for intubation without neuromuscular blockade
Sponsors
University of Brasilia
Brasilia University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
2 Years to 9 Years
Healthy volunteers
Yes
Inclusion criteria
* ASA I or II * Scheduled for surgery under general anesthesia.
Exclusion criteria
* Predicted difficult airway * Severe neurologic or cardiologic conditions * Recent upper airway infectious diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of Adequate intubation condition (dichotomic) as an assessment of success rate | intraoperative | Intubation is adequate if patient does not cough, does not try to breathe, vocal cords do not move, patient does not react and laringoscopy is Cormack class I or II |
Outcome results
None listed