Female Infertility
Conditions
Keywords
Ovarian cortex cryopreservation, ovarian function
Brief summary
Evaluation of ovarian function by a questionnaire and by medical file analysis of women and girls who underwent ovarian cortex cryopreservation for fertility preservation between 1997 an 2013 in the investigators' institution in order to evaluate their residual ovarian function. A second part of the questionnaire concerns these women's satisfaction regarding the procedure.
Detailed description
Between 1997 and december 2013, 546 girls and women underwent ovarian cortex cryopreservation in the investigators' institution for fertility preservation. The main indications were the need for a gonadotoxic treatment, repeated ovarian surgery and a genetic risk for premature ovarian failure . These women will be sent a questionnaire concerning their ovarian function since the procedure and a questionnaire about their satisfaction concerning the procedure. Six different questionnaires will be used adapted to the patient's initial indication for cryopreservation and the patient's age at the time of cryopreservation. Complementary data will be obtained by medical file analysis and by contacting the patient's family doctor or gynecologist. Data will be correlated with received gonadotoxic treatment and surgical interventions. The purpose of the study is to improve the indications and patient selection for ovarian cortex cryopreservation.
Interventions
OTHERquestionnaire
A questionnaire will be send concerning the patient's ovarian function since the cryopreservation procedure i.e: progression of puberty, menstrual cycle, hormonal treatment, desire for pregnancy, occurence of pregnancy, details of pregnancy, need for ART (Artificial Reproductive Techniques), and about the patient's satisfaction concerning the cryopreservation procedure. Data collected will be correlated with treatments received.
Sponsors
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
* women who underwent ovarian cortex cryopreservation in our institution between 1997 and 2013
Exclusion criteria
* deceased women in this cohort
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Persistence of ovarian function | since the cryopreservation procedure (24 up to 216 months) | Prove of ovarian function will be the occurence of pregnancy, the presence of menstrual cycles without hormonal treatment based on the questionnaire or on biological findings compatible with ovarian function in medical file |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Satisfaction with the undergone cryopreservation procedure | at the time of completion of the questionnaire (24 up to 216 months after the cryopreservation procedure) | The questionnaire will evaluate the patient's satisfaction concerning the cryopreservation procedure |
Countries
Belgium
Outcome results
None listed