Anesthesiology Management
Conditions
Keywords
Sugammadex, Delayed Emergence from Anesthesia, Curare, Robotic Surgical Procedures
Brief summary
With the aim of enhancing the quality of surgery, the robotic cystectomy is often conducted using continuous intravenous infusion of curare, which ensures maximum neuromuscular relaxation until the end of the intervention. Sugammadex, administered for the reversal of deep neuromuscular blocked, enable rapid awakening. Moreover, Sugammadex seems to have a positive effect also on the recovery of cognitive function, psychomotor coordination and mental ability, effects undocumented in Literature. The aim of the investigators study was to assess whether the reversal with sugammadex after intraoperative continuous infusion of rocuronium, can improve the quality of awakening.
Interventions
DRUGsugammadex
DRUGNeostigmine
Sponsors
Regina Elena Cancer Institute
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* ASA score ≤ III * Patients underwent robotic cystectomy
Exclusion criteria
* Cerebrovascular disease * BMI ≥ 30
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| average score obtained on awakening according to specific test | 16 months | cognitive function as assessed by the Mini Mental State Exam; quality of awakening as assessed by the Observer's Assessment of Alterness/sedation |
Countries
Italy
Outcome results
None listed