Eosinophilic Esophagitis
Conditions
Keywords
Eosinophilic Esophagitis, Esophageal Stricture
Brief summary
This protocol addresses a central hypothesis that fibrostenotic Eosinophilic Esophagitis (EoE) is characterized by abnormal esophageal structure and compliance compared to non fibrostenotic EoE and that distinctive cellular and molecular profiles predict the fibrostenotic phenotype. This study aims to define and assess the changes that occur in the structure and dynamics of the esophageal wall in pediatric Eosinophilic Esophagitis along with characterizing the histologic and molecular patterns in fibrostenotic EoE.
Interventions
None listed
Sponsors
University of Colorado, Denver
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
5 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
* Scheduled to undergo a clinical upper endoscopy with biopsy
Exclusion criteria
* Known connective tissue disorder * Increased risk of bleeding * Inflammatory bowel disease, celiac disease, eosinophilic gastroenteritis, or any autoimmune disease * Other esophageal disease including known achalasia; history of caustic ingestion, esophageal surgery esophageal stricture for other known reason or other esophageal injury. * Use of oral or intravenous steroids in the preceding 60 days. (Swallowed topical fluticasone, budesonide, etc not included as
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Stricture, as measured by endoscopic assessment | Day 1 |
Secondary
| Measure | Time frame |
|---|---|
| Decreased esophageal distensibility, as determined by EndoFlip | Day 1 |
Countries
United States
Contacts
Primary ContactCassandra Burger
Outcome results
None listed