Burns, Chickenpox, Cytomegalovirus, Herpes Simplex Virus, Human Herpes Virus, Varicella-zoster Virus
Conditions
Brief summary
Herpes simplex virus, cytomegalovirus and varicella zoster virus infection are purported to play a pivotal role in morbidity and mortality in burns. Thus far, there is no existing systematic review (Level of Evidence III or higher) describing the unique role as well as concurrent infections of these viruses in burns. The aim of this review is to point out the clinical differences between these human herpes virus subtypes, to outline established therapy approaches, and to provide evidence for virus related morbidity and mortality in burns.
Detailed description
This systematic review was created according the PRIMSA (preferred reporting items for systematic reviews and meta-analyses) guidelines and checklist. We performed an review of the medical literature to identify all studies that contain HSV, CMV and VZV infections in burns.Therefore, systematic review of the Medline database by using PubMed and Ovid interface was conducted. Also the Web of Science interface was used for systematic literature search. On the PubMed interface, we used the following search terms: (HSV\[All Fields\] OR herpes\[All Fields\] OR CMV\[All Fields\] OR cytomegalovirus\[All Fields\] OR VZV\[All Fields\] OR varicella-zoster\[All Fields\]) AND (burns\[MeSH Terms\] OR burns\[All Fields\] OR burn\[All Fields\] OR thermal trauma\[All Fields\]). For Ovid we used: exp Burns/ AND (exp Herpes Zoster/ or exp Encephalitis, Herpes Simplex/ or exp Herpes Simplex/ or exp Herpes Simples Virus Vaccines/), exp Burns/ AND (exp Cytomegalovirus/ or exp Cytomegalovirus Infections/), exp Burns/ AND (exp Chickenpox/ or Herpesvirus 3. Human/ or exp Herpes Zoster/). And for Web of Science we used: (TS=(HSV OR herpes OR CMV OR cytomegalovirus OR VZV OR varicella-zoster) AND TS=(burn OR burns OR thermal trauma)) AND LANGUAGE: (English) AND DOCUMENT TYPES: (Article); Timespan: All years; Indexes: SCI-EXPANDED, SSCI, A&HCI, CPCI-S.
Interventions
OTHERReview of the Literature for Human Herpes Virus infections
Review of the Medline database (PubMed and Ovid interface) for human herpes virus infections in burns as well as Web of Science interface. PRIMSA (preferred reporting items for systematic reviews and meta-analyses) guidelines and checklist were used.
Sponsors
Shriners Hospitals for Children
The University of Texas Medical Branch, Galveston
Study design
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Patients who presented with at least 1% TBSA burned * Patients who presented with a viral infections during their hospitalization
Exclusion criteria
* Patients who had no burns * Patients who had no viral infections during their hospitalization
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of Human Herpes Virus (HHV) Infections | Participants will be followed for the duration of hospital stay, an expected average of 3 months. | HHV include the herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), varicella zoster virus (VZV), cytomegalovirus (CMV), Epstein-Barr viruses (EBV) and human herpes virus 6 to 8 |
Secondary
| Measure | Time frame |
|---|---|
| Treatment of Human Herpes Virus (HHV) Infections | Participants will be followed for the duration of hospital stay, an expected average of 3 months. |
Outcome results
None listed