Vitamin D Deficiency
Conditions
Brief summary
The investigators major aims are to: determine the vitamin D status of a group of young, apparently healthy adults in Hong Kong; examine inter-relationships between vitamin D status and biomarkers of DNA damage and repair, oxidative stress, inflammation and endothelial health; and, in part 2 of the study, investigate effects of improvement in vitamin D status on these biomarkers and other measures of well-being in those young adults shown to be deficient in vitamin D.
Detailed description
In this part 2 of the study the investigators will investigate the effect of vitamin D supplementation on biomarkers of these 'hidden' changes in apparently healthy young adults. The investigators will also explore the effect of improvement in vitamin D status in young apparently healthy adults in regard to muscular strength and response time, glucose control, a hormone that is linked to vitamin D (parathyroid hormone (PTH) ) and mood.
Interventions
DIETARY_SUPPLEMENTVitamin D
2400 units per day for 3 months
Sponsors
The Hong Kong Polytechnic University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 26 Years
Healthy volunteers
Yes
Inclusion criteria
* apparently healthy, non-smokers * non-obese * found (in part1) to have low vitamin D status
Exclusion criteria
* chronic illness * serious illness requiring medical treatment in previous 6 months * pregnancy * on regular medication or taking supplements on a regular basis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| biomarkers of oxidative stress | 3 months |
Countries
Hong Kong
Outcome results
None listed