Kidney Failure
Conditions
Brief summary
Cardiovascular disease is the leading cause of death of dialysis patients and poor fluid management is associated with the increased risk. One of the principal limitations in avoiding chronic fluid overload in this patient group is the refilling rate the rate at which fluid is transferred from tissues into the vascular system. If this rate cannot match the prescribed rate of fluid removal during dialysis the patient will end up with chronic fluid overload. Two proposed methods of increasing the rate of refilling are intermittent pneumatic compression (IPC) devices, which increase the pressure of the fluid in tissue, and neuromuscular electrical stimulation (NMES) which activates the muscle pump and lymphatic drainage. This investigation will trial the use of these two methods in patients suspected of having inadequate refilling rates. Outcome measures will be based on fluid status, presence of oedema and quality of life.
Interventions
DEVICEIntermittent pneumatic compression device
Flowtron, Circulation Booster and Sports XL devices will be used.
DEVICENeuromuscular electrical stimulation
Flowtron, Circulation Booster and Sports XL devices will be used.
Sponsors
National Institute for Health Research, United Kingdom
The Leeds Teaching Hospitals NHS Trust
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Presence of lower limb oedema as defined by pitting * Average post dialysis fluid overload in relation to target weight greater than 0.5 litres * Greater than one dialysis session that included an intradialytic hypotensive episode in the previous month, defined by saline influsion or nursing intervention
Exclusion criteria
* Less than 18 years of age * Less than 3 months dialysis vintage * Presence of metal implants, amputations or the inability to be weighed
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Fluid Status (Body composition monitor measurement of fluid status) | Weekly | Body composition monitor measurement of fluid statu |
| Quality of Life (Validated Kidney Disease Quality of Life (KDQOL36) quality of life measurement questionnaire and patient symptom questionnaire) | Weekly | Validated KDQOL36 quality of life measurement questionnaire and patient symptom questionnaire |
Countries
United Kingdom
Contacts
Primary ContactDavid Keane, MSc, CSci
Outcome results
None listed