Asthma, Exhaled Breath, Mass Spectrometry
Conditions
Brief summary
The purpose of this study is to answer the question whether a disease-specific profile of breath in patients with asthma can be detected by an untargeted metabolomic study using exhaled breath analysis by mass spectrometry.
Interventions
OTHERno intervention
Sponsors
Swiss Federal Institute of Technology
University of Zurich
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
1. Confirmed asthma. Diagnosis of asthma is made with episodic chest symptoms and a documented reversibility of at least 12% and/or 200 ml in FEV1 after 200 ug of inhaled salbutamol or airway hyperresponsiveness in the case of normal lung function testing (PC20 methacholine \< 4mg/ml) at the time of diagnosis. 2. Age between 18 and 80 years at study entry. 3. Healthy controls: never-smokers, normal spirometry (baseline FEV1 \> 85% predicted and FEV1/FVC greater than 0.7).
Exclusion criteria
1. Asthma exacerbation within the last 6 weeks, defined as worsening of asthma symptoms requiring a change in therapy by a physician or a change in regular asthma therapy (including short course of oral corticosteroids) 2. Any lung disease other than asthma. 3. Acute inflammatory disease (e.g. common cold) within the last 4 weeks. 4. Regular intake of oral steroids. 5. Active smoking habits / positive history of smoking. 6. Acute or chronic hepatic disease. 7. Renal failure or renal replacement therapy. 8. Pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome will be the asthma specific mass spectrometric profile of VOCs of exhaled breath analysis (markers of asthma in exhaled breath) | 1 day, single measurement, no follow up |
Countries
Switzerland
Outcome results
None listed