Nonobstructive Coronary Artery Disease
Conditions
Brief summary
The purpose of this study is to examine the acute effect of exercise on vascular function in women with nonobstructive coronary artery disease.
Detailed description
Women are more likely to have nonobstructive coronary artery disease (CAD) . The purpose of this study is to examine the acute effect of exercise on vascular function in women with nonobstructive coronary artery disease. Endothelium-dependent and -independent dilation, arterial stiffness and wave reflection will be measured at baseline and after walking on a treadmill at a slow pace for 47 minutes. Endothelium-dependent dilation will be measured using brachial artery flow-mediated dilation via high resolution ultrasonography. Endothelium-independent dilation will be measured using brachial artery dilation to sublingual nitroglycerin. Arterial stiffness and wave reflection will measured using applanation tonometry.
Interventions
OTHERSlow-paced walking
Subjects will walk on a treadmill at a slow pace for 47 minutes
Sponsors
University of Florida
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 89 Years
Healthy volunteers
No
Inclusion criteria
* women with non-obstructive coronary artery disease documented within the past 5 years by coronary angiogram as no coronary arteries with stenosis greater than 50% lesions * age 18 to 89 years * able to complete maximal graded exercise test
Exclusion criteria
* use of tobacco products within the previous six months * use of oral contraceptives or hormone replacement therapy within the prior year * pregnancy (positive urine pregnancy test) or lactation * history of hepatic disease or infection with hepatitis B, C or HIV
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in endothelium-dependent dilation | Baseline, 15 minutes after exercise and 1 hour after exercise | Brachial artery endothelium-dependent flow-mediated dilation to reactive hyperemia will be measured using high resolution ultrasonography. To determine flow-mediated dilation, brachial artery diameter and blood velocity will be measured before and after occluding the forearm for 5 minutes by inflating a cuff to 250 mmHg. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in endothelium-independent dilation | Baseline, 15 minutes after exercise | To determine vascular smooth muscle responsiveness to nitric oxide, brachial artery diameter will be measured using high resolution ultrasonography before and after sublingual administration of 0.4mg nitroglycerin. |
| Change in arterial stiffness and wave reflection | Baseline, 15 minutes after exercise and 1 hour after exercise | Aortic pulse wave velocity and augmentation index will be measured using applanation tonometry. |
Countries
United States
Outcome results
None listed